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EC number: 209-813-7 | CAS number: 593-85-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Ecotoxicological Summary
Administrative data
Hazard for aquatic organisms
Freshwater
- Hazard assessment conclusion:
- PNEC aqua (freshwater)
- PNEC value:
- 214 µg/L
- Assessment factor:
- 10
- Extrapolation method:
- assessment factor
- PNEC freshwater (intermittent releases):
- 306 µg/L
Marine water
- Hazard assessment conclusion:
- PNEC aqua (marine water)
- PNEC value:
- 21.4 µg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
STP
- Hazard assessment conclusion:
- PNEC STP
- PNEC value:
- 1.16 mg/L
- Assessment factor:
- 100
- Extrapolation method:
- assessment factor
Sediment (freshwater)
- Hazard assessment conclusion:
- PNEC sediment (freshwater)
- PNEC value:
- 1.2 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Sediment (marine water)
- Hazard assessment conclusion:
- insufficient hazard data available (further information necessary)
- PNEC value:
- 0.12 mg/kg sediment dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for air
Air
- Hazard assessment conclusion:
- no hazard identified
Hazard for terrestrial organisms
Soil
- Hazard assessment conclusion:
- PNEC soil
- PNEC value:
- 114 µg/kg soil dw
- Extrapolation method:
- equilibrium partitioning method
Hazard for predators
Secondary poisoning
- Hazard assessment conclusion:
- no potential for bioaccumulation
Additional information
The ecotoxicological Chemical Safety Assessment of Guanidine Carbonate bases on a full short- and long-term aquatic dataset, which indicates no relevant hazard to the aquatic environment or the microorganism communities in sewage water treatment plants. Due to the absence of high toxicity and persistence, the submission item falls into the low hazard soil toxicity class. Some literature data confirm the absence of effects to soil organisms up to high levels.
Therefore Guanidine Carbonate can be considered of low hazard for the environment.
Conclusion on classification
The text in COMMISSION REGULATION (EU) No 286/2011 of 10 March 2011 amending, for the purposes of its adaptation to technical and scientific progress, Regulation (EC) No 1272/2008 of the European Parliament and of the Council on classification, labelling and packaging of substances and mixtures, Official Journal of the European Union L 83/1-53, of 30.3.2011 replaces Part 4 of Annex I to Regulation (EC) No 1272/2008 is replaced and is thus used for classification.
Acute aquatic hazard
The acute aquatic hazard is according to table 4.1.0 a), page 21 relevant for classification if at least one of the three trophic levels shows a L(E)C50 of 1 mg/L or lower. The experimental L(E)C50 values were 65, 41 and >100 mg/L for algae, crustaceans and fish, respectively.
Thus no acute aquatic classification is required.
Long-term aquatic hazard
The submission item guanidine carbonate is not rapidly biodegradable as the modified OECD screening test of Kocsis (1998) revealed only 0.1 % degradation in 28 days. Thus table 4.1.0 b) i) applies.
As no long-term studies on crustaceans and fish are available for the submission item the classification bases on guanidine mononitrate (CAS 506-93-4) experiments. It is assumed and confirmed by QSPR (ChemAxon MarvinSketch version 5.3.6) that the protonated guanidine represents in the pH range from 0-10 more than 99 % of the guanidine species. Thus both guanidine mononitrate (source chemical) and guanidine carbonate (target chemical) are fully dissociated and aquatic organisms are exposed to the same chemical entities independent from the initially used salt. Solely the anions differ. As carbonate species are considered non-toxic, any read across from the nitrate to the carbonate on a molar guanidine basis seems justified. As the guanidine kation is univalent, the conversion factor equal to the mass ratio MW (CH5N3 + ½CH2O3) / MW (CH5N3 + HNO3), i.e. (59.071 + 62.025/2) / (59.071 + 63.013) = 90.0835 / 122.083, which gives ca. 0.74. Accordingly the classification is based on the chronic NOEC data of the nitrate of 181 mg/L ∙ 0.74 = ca. 134 mg/L for the fish, 2.9 mg/L ∙ 0.74 = ca. 2.14 mg/L for the daphnids and of the algal – NOEC of the carbonate, 4 mg/L. The lowest value is thus 2.14 mg/L, which is above the classifiable range. As all chronic NOEC were above 1 mg/L and the bioaccumulation potential based on the log Kow of ≤ -1.43 (Junghans 2009) or the BCF of the test surrogate guanidine (CAS 113-00-8) is low (< 0.1 to 0.1), no safety net classification is required.
Thus no long-term aquatic hazard classification is required.
Hazard to the ozone layer
Due to its chemical structural elements any ozone depleting potential of the submission item seems unlikely.
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