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EC number: 209-813-7 | CAS number: 593-85-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: - meets generally accepted scientific principles - sufficient information for assessment reported
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- yes
- Remarks:
- post exposure period only 7 d
- GLP compliance:
- no
- Remarks:
- study predates implementation of GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Diguanidinium carbonate
- EC Number:
- 209-813-7
- EC Name:
- Diguanidinium carbonate
- Cas Number:
- 593-85-1
- Molecular formula:
- CH5N3.1/2CH2O3 (one guanidine species, as denoted in the ESIS database) CH5N3.CH5N3.CH2O3 (as in the crystalline from, basis for the molecular weight 180.1658 g/mol as given below)
- IUPAC Name:
- bis(amino(imino)methanaminium) carbonate
- Details on test material:
- - Name of test material (as cited in study report): Guanidinkarbonat
- Physical state: not reported, but assumed to be a solid powder
- Analytical purity: 99.4 %
- Impurities (identity and concentrations):
• Melamin: 0.1 %
• Urea: 0.34 %
• Fe: 25 ppm
- Lot/batch No.: not reported
- Stability under test conditions: not reported, but assumed to be stable
- Storage condition of test material: not reported
- Number of certificate of analysis: BPH/Wö/A1 of 1978-01-05
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: own breeding facility
- Age at study initiation: not reported
- Weight at study initiation: 150 - 200 g
- Fasting period before study: 2 - 3 hours prior to oral application until 2 - 3 hours after application, food was removed. Water was given immediately after application.
- Housing: 5 per cage, Makrolon R cage
- Diet (e.g. ad libitum): ALTROMIN R-R-pellets, ad libitum
- Water (e.g. ad libitum): not reported
- Acclimation period: not reported, but raised in own breeding facility
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 26 ± 1
- Humidity (%): 50 - 60
- Air changes (per hr): not reported
- Photoperiod (hrs dark / hrs light): not reported
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- test substance applied as 13.3 % aqueous solution
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 13.3 %
- Amount of vehicle (if gavage): 4.45, 6.7, 10, 15 ml/kg bw
- Justification for choice of vehicle: The test item was known to be sufficiently water soluble
MAXIMUM DOSE VOLUME APPLIED: 15 mL/kg - Doses:
- 592, 889, 1333 and 2000 mg/kg bw,
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 7 d
- Frequency of observations and weighing: not reported
- Necropsy of survivors performed: not reported
- Other examinations performed: clinical signs, body weight, organ weights, histopathology, other: not reported - Statistics:
- Thompson-Weil (Thompson WRT and Weil CS, 1952, Biometrics 8:51-4; Weil CS, 1952, Biometrics 8:249-63).
Tables from this article were supplemented with r-values by the company's data processing centre.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 089 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 934 - <= 1 296
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 045 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 914 - <= 1 197
- Mortality:
- see table 1 for details
- Clinical signs:
- other: not reported
- Gross pathology:
- not reported
Any other information on results incl. tables
- Table 1: Mortality in Sprague-Dawley rats
Dose in mg/kg bw |
fatalities within 7 d post dosing |
|
females |
males |
|
592 |
0/10 |
0/10 |
889 |
2/10 |
1/10 |
1333 |
9/10 |
10/10 |
2000 |
10/10 |
10/10 |
LD50 in mg/kg bw |
1045 |
1089 |
95 % confidence limits |
(914 - 1197) |
(934 - 1269) |
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Guanidine carbonate was tested for its acute oral toxicity in Sprague-Dawley rats of both sexes after single oral treatment following a procedure generally equivalent to OECD TG 401. Doses used were 592, 889, 1333 and 2000 mg/kg bw. Post exposure observation period was 7 d.
The LD50 values for males and females are 1089 mg/kg bw (95 % CL: 934 – 1296) and 1045 mg/kg bw (95 % CL: 914 – 1197) respectively. - Executive summary:
Guanidine carbonate was tested for its acute oral toxicity in Sprague-Dawley rats of both sexes after single oral treatment following a procedure generally equivalent to OECD TG 401. Doses used were 592, 889, 1333 and 2000 mg/kg bw. Post exposure observation period was 7 d.
LD50 values were determined by the method of Thompson-Weil.
The LD 50 values for males and females are 1089 mg/kg bw (95 % CL: 934 – 1296 mg/kg bw) and 1045 mg/kg bw (95 % CL: 914 – 1197 mg/kg bw), respectively.
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