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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Toxicity to aquatic algae and cyanobacteria

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Administrative data

Link to relevant study record(s)

Description of key information

QSAR calculation gives an estimates 96hr EC50 for algae of 2.356 mg/l.

Key value for chemical safety assessment

EC50 for freshwater algae:
2.356 mg/L

Additional information

A standard algal toxicity test is not available for 1, 2, 4-trimethylbenzene. In the absence of measured data the use of a QSAR to predict the ecotoxicity of 1, 2, 4-trimethylbenzene is an appropriate technique to use when assessing whether this substance would meet the criteria for PBT and potential classification. The ECOSAR model is a reliable and appropriate QSAR model to apply to 1, 2, 4-trimethylbenzene as it is based on a related chemical dataset that calculates the toxicity of neutral organic hydrocarbons whose mode of action is non-polar narcosis. The endpoint calculated here is therefore a reasonable estimate of its baseline toxicity. The result does not indicate that 1,2,4-trimethylbenzene would meet the criteria for toxic in the PBT assessment. This endpoint would not affect the classification of the 1, 2, 4-trimethylbenzene since the substance is biodegradable and the log Kow is < 4.0.