Registration Dossier
Registration Dossier
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EC number: 202-436-9 | CAS number: 95-63-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, non-guideline study, available as unpublished report, restrictions in design and/or reporting but otherwise adequate for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- as described by Noakes DN and Sanderson DM (1969), A method for determining the dermal toxicity of pesticides. Br. J. Indust. Med., 26, 59-64
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Solvent naphtha (petroleum), light arom.
- EC Number:
- 265-199-0
- EC Name:
- Solvent naphtha (petroleum), light arom.
- Cas Number:
- 64742-95-6
- IUPAC Name:
- 64742-95-6
- Reference substance name:
- Shellsol A
- IUPAC Name:
- Shellsol A
- Details on test material:
- - Name of test material (as cited in study report): Shellsol A
- Substance type: hydrocarbon solvent (essentially C9 isomers, particularly trimethylbenzenes)
- Physical state: liquid
- Source: Shell Nederland Raffinarderij B.V. refinery, Pernis, Rotterdam, The Netherlands
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- other: CD (COBS)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Source: Charles River (UK) Ltd., Manston, Kent, UK
- Age at study initiation:no data
- Weight at study initiation: no data
- Housing: no data
- Diet (e.g. ad libitum): no data
- Water (e.g. ad libitum): no data
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS: no data
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Duration of exposure:
- 24 hours
- Doses:
- 1, 2, 4 mL/kg bw
- No. of animals per sex per dose:
- 2
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: no data
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no - Statistics:
- not applicable
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 other: mL/kg bw (3440 mg/kg)
- Remarks on result:
- other: no mortalities at 4 mL/kg bw (highest dose tested)
- Mortality:
- no mortalities
- Clinical signs:
- none
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute dermal LD50 of Shellsol A was greater than 4 mL/kg bw to male and female rats.
- Executive summary:
The acute dermal toxicity of Shellsol A was low, the 24 hour LD50 in rats was greater than 4 mL/kg bw to male and female rats (i.e. >3440 mg/kg).
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