Registration Dossier
Registration Dossier
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EC number: 289-064-0 | CAS number: 85959-68-8
Sediment toxicity
Administrative data
Link to relevant study record(s)
Description of key information
There is no sediment toxicity data for DTPA-Fe(NH4)2. However, based on a log Kow <3 and low predicted adsorption and binding of DTPA, sediment testing is not necessary.
Key value for chemical safety assessment
Additional information
The log Kow for DTPA-Fe(NH4)2 is -13.9, therefore sediment testing is not required since DTPA-Fe(NH4)2 is not expected to partition to sediments in the aquatic environment. Furthermore, DTPA is not expected to adsorb to sediments based upon the known behaviour of EDTA, a structural analogue, which can be used for read across as justified in section 13.
In a laboratory test, solutions of H4 -EDTA and Zn-EDTA were eluted through various surface soils and were found to move quite readily through the soils and be only very slightly adsorbed (Cheng et al., 1972). A model calculation of the distribution of EDTA metal complexes between water and suspended solids resulted in a finding that <1% of the total EDTA is adsorbed, and according to the fugacity model Mackay level I, the preferred environmental component for EDTA is the hydrosphere (99.999%) (EU, 2004). Read-across from EDTA to DTPA is supported by the fact that the EDTA and DTPA have similar chemical structures and the same mechanism of action (chelation of metals).Thus, based on a read across approach from EDTA, low adsorption is predicted for DTPA, and sediment testing is therefore further demonstrated to be not necessary for DTPA.
- Cheng SM, Thomas RL, Elrick DE. 1972. Reactions and movements of EDTA and ZnEDTA in soils. Can. J. Soil. Sci. 52:337 -341.
- European Union (EU). 2004. European Union Risk Assessment Report: edetic acid (EDTA)
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