Registration Dossier
Registration Dossier
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EC number: 405-800-7 | CAS number: 27955-94-8 THPE; TRIS(P-HYDROXYPHENYL)ETHANE; TRIS(PARA-HYDROXYPHENYL)ETHANE
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- Remarks:
- The study was conducted according to the test guidelines in effect at the time of study conduct.
- GLP compliance:
- yes
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Type:
- log Pow
- Partition coefficient:
- 3.88
- Temp.:
- 20 °C
- pH:
- 6.53 - 6.77
- Conclusions:
- The partition coefficient of the test substance was determined to be log P = 3.88 at 20ºC.
- Executive summary:
The partition coefficient (n-octanol/water) of the test substance was determined in accordance with EEC Directive 67/548 Annex V, A8 as published in 84/449/EEC. The report includes calibration data, the concentration of the test substance in stock octanol solution, the concentration and total mass of test substance in aqueous and octanol test phases after partition, calculation of partition coefficients, and the mass balance. All of the test substance used can be accounted for. The partition coefficient of the test substance was determined to be log P = 3.88 at 20ºC.
Reference
Description of key information
EU Method A.8
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.88
- at the temperature of:
- 20 °C
Additional information
pH 4.37-5.62
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