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Toxicological information

Repeated dose toxicity: inhalation

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Administrative data

Endpoint:
short-term repeated dose toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report date:
1971

Materials and methods

Principles of method if other than guideline:
Six male rats were exposed whole body to the test substance for four hours per day for ten days. Six control rats were exposed to air for the same period of time. Gross and histopathologic examinations were performed on three rats from each group after the last exposure and 14 days post-exposure.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Terephthaloyl dichloride
EC Number:
202-829-5
EC Name:
Terephthaloyl dichloride
Cas Number:
100-20-9
Molecular formula:
C8H4Cl2O2
IUPAC Name:
benzene-1,4-dicarbonyl dichloride
Constituent 2
Reference substance name:
Terephthaloyl chloride
IUPAC Name:
Terephthaloyl chloride
Details on test material:
- Purity: 99.9%

Test animals

Species:
rat
Strain:
other: ChR-CD
Sex:
male

Administration / exposure

Route of administration:
inhalation: aerosol
Type of inhalation exposure:
whole body
Vehicle:
other: air (nitrogen carried aerosol into test chamber where it was then mixed with additional oxygen and diluting air to achieve a 20% O2 (v/v) level)
Analytical verification of doses or concentrations:
yes
Duration of treatment / exposure:
4 hours
Frequency of treatment:
One time per day for 10 days
Doses / concentrations
Dose / conc.:
0.087 other: ± 0.010 mg/L
Remarks:
average concentration
No. of animals per sex per dose:
6
Control animals:
yes, sham-exposed

Results and discussion

Results of examinations

Description (incidence and severity):
During exposure period rats did not gain weight normally; during post exposure weight gain was normal.
Description (incidence and severity):
No significant histopathological changes.

Effect levels

Dose descriptor:
dose level:
Effect level:
0.087 mg/L air
Sex:
male
Basis for effect level:
other: suppressed growth rate during exposures; growth rate normal during recovery

Target system / organ toxicity

Critical effects observed:
no

Applicant's summary and conclusion

Conclusions:
In rats exposed by inhalation to 0.087 mg/L for four hours for ten days weight gain suppression was observed during exposure and was normal during recovery. No significant treatment related histophathological changes were found.
Executive summary:

Six male rats were exposed whole body to 0.087 mg/L of the test substance for four hours per day for ten days. Six control rats were exposed to air for the same period of time. Gross and histopathologic examinations were performed on three rats from each group after the last exposure and 14 days post-exposure. In rats exposed by inhalation to 0.087 mg/L for four hours for ten days weight gain suppression was observed during exposure and was normal during recovery. No significant treatment related histophathological changes were found.