Registration Dossier
Registration Dossier
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EC number: 222-359-4 | CAS number: 3445-11-2
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard.
- GLP compliance:
- no
Test material
- Reference substance name:
- 1-(2-hydroxyethyl)pyrrolidin-2-one
- EC Number:
- 222-359-4
- EC Name:
- 1-(2-hydroxyethyl)pyrrolidin-2-one
- Cas Number:
- 3445-11-2
- Molecular formula:
- C6H11NO2
- IUPAC Name:
- 1-(2-hydroxyethyl)pyrrolidin-2-one
- Details on test material:
- Name of the test substance used in the study report: 1-(2-hydroxyethyl)pyrrolidone-2
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Kisslegg
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Details on exposure:
- The test substance was given as a 2, 20 or 30% (v/v) aqueous solution
- Doses:
- 200, 1600, 3200, 4000, 5000, 5600, 6400 mm3/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 6 000 other: mm3/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: original value
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 6 900 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: calculated from original value
- Mortality:
- 200, 1600, 3200 and 4000 mm3/kg: no mortalities
5000 mm3/kg: 2/5 female animals after 14 days
5600 mm3/kg: 1/5 males after 14 days
6400 mm3/kg: 3/5 males and 4/5 females after 14 days. - Clinical signs:
- Dyspnea, abdominal and lateral positions and convulsions.
- Body weight:
- No datails given in study report.
- Gross pathology:
- No abnormalities detected.
Applicant's summary and conclusion
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