3,7-dimethylnona-1,6-dien-3-ol

Endpoint summary

Description of key information

Acute toxicity oral:
- The oral LD50 in mice for ethyllinalool was determined to be 5283 mg/kg bw.
- The oral LD50 in rats for ethyllinalool was determined to be 5000 mg/kg bw.
Acute toxicity inhalation:
- The inhalative LC50 in rats for dehydrolinalool was determined to be greater than 1.0 mg/l.
- The inhalative LC50 in mice for linalool was determined to be greater than 3.2 mg/l.
Acute toxicity dermal:
- The dermal LD50 in rabbits for ethyllinalool was determined to be greater than 5000 mg/kg bw.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

5 283 mg/kg bw

Acute toxicity: via dermal route

Endpoint conclusion

Endpoint conclusion:

no adverse effect observed

Dose descriptor:

LD50

Value:

5 000 mg/kg bw

Additional information

Ethyllinalool, linalool (CAS 78-70-6) and dehydrolinalool (CAS 29717-20-8) are structurally related substances having similar chemical structures. Difference between linalool and dehydrolinalool is the triple bond at position 1 in dehydrolinalool compared to a double bond at the same position in linalool. Both substances have similar physical-chemical properties. Ethyllinalool is a structural homologue of Linalool which differs by a methyl-group only. The physical-chemical properties of ethyllinalool are comparable to the two other substances and available experimental data on the same toxicological endpoints, showed identical toxicological properties. Therefore, it is assumed that all toxicological properties are as well comparable and thus Read-Across is justified.

Experimental data with Ethyllinalool showed that the acute oral LD50 in rats and mice is greater than 2000 mg/kg bw, the acute dermal LD50 > 5000 mg/kg bw in rabbits. Very similar results have been obtained for linalool and dehydrolinalool. Although no data are available for ethyllinalool on acute inhalation, based on read across the LC50 is expected to be greater than 3.2 mg/L (highest concentration tested). Acute inhalation toxicity was not tested by standard means. However, there were no deaths at a concentration of 3.2 mg linalool/L and 1.0 mg dehydrolinalool/L.

Justification for classification or non-classification

Based on the available information ethyllinalool has been shown to be of low acute toxicity when applied via the oral, dermal. Based on a read across approach to linalool and dedydrolinalool, ethyllinalool is also expected to be of low acute toxicity through the inhalation route. Therefore, the substance ethyllinalool does not need to be classified for acute toxicity according to the criteria outlined in Annex I of 1272/2008/EC (CLP/EU-GHS).