3,7-dimethylnona-1,6-dien-3-ol

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

key study

Study period:

10/02/1988 - 24/02/1988

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Ethyllinalool and dehydrolinalool have similar chemical structures. They differ in the triple bond at position 1 in dehydrolinalool compared to a double bond in ethyllinalool as well as in an additional methyl-group for ethyllinalool. Both substances have almost identical physical-chemical properties and available experimental data on same toxicological endpoints, showed identical toxicological properties. Therefore, it is assumed that toxicological properties are as well comparable and thus read-across is justified.

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1988

Report date:

1988

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Principles of method if other than guideline:

No remarks

GLP compliance:

no

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

3,7-dimethyloct-6-en-1-yn-3-ol

EC Number:

249-482-6

EC Name:

3,7-dimethyloct-6-en-1-yn-3-ol

Cas Number:

29171-20-8

Molecular formula:

C10H16O

IUPAC Name:

3,7-dimethyloct-6-en-1-yn-3-ol

Details on test material:

- Name of test material (as cited in study report): Dehydrolinalool
- Physical state: liquid, slightly yellowish
- Expiration date of the lot/batch: at least for the time range of the current test
- Storage condition of test material: room temperature

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: Dr. K. Thomae GmbH, 7950 Biberach
- Age at study initiation: 8-9 weeks
- Weight at study initiation: males 280 g, females 216 g
- Housing: 3 animals in a cage type D III (Becker & Co.)
- Diet (e.g. ad libitum): ad libitum in the exposition free period
- Water (e.g. ad libitum): ad libitum in the exposition free period
- Acclimation period: at least 5 days

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24 °C
- Humidity (%): 30-70 %
- Photoperiod (hrs dark / hrs light): 12

Administration / exposure

Route of administration:

inhalation

Type of inhalation exposure:

whole body

Vehicle:

air

Details on inhalation exposure:

Exposure atmosphere was generated using a test substance filled flask which was held at 20°C. Test substance was weighed in the flask. An airflow with 200 L/h was conveyed through the flask and the generated test atmosphere was conveyed to the animals held in glass animal restrainers. After 30 minutes, a new flask was used.

Duration of exposure:

7 h

Concentrations:

The amount of test substance used was determined by weighing. The nominal concentration was calculated using the amount of substance used and the airflow. The nominal concentration was 1 mg/L.

No. of animals per sex per dose:

3

Control animals:

not specified

Details on study design:

Animals were examined for clinical signs up to 14 days.

Statistics:

No remarks

Results and discussion

Preliminary study:

No remarks

Effect levels

Sex:

male/female

Dose descriptor:

LC50

Effect level:

> 1 mg/L air (nominal)

Remarks on result:

other: highest concentration tested

Mortality:

All animals survived.

Clinical signs:

other: During exposure clinical signs consisted of increased breathing rate and snout wiping.

Body weight:

No remarks

Gross pathology:

No findings were seen at necropsy.

Other findings:

Not relevant

Any other information on results incl. tables

Read across:

Linalool (CAS 78-70-6), dehydrolinalool, and ethyllinalool are structurally related substances having similar chemical structures. Difference between linalool and dehydrolinalool is the triple bond at position 1 in dehydrolinalool compared to a double bond at the same position in linalool. Both substances have similar physical-chemical properties. Ethyllinalool is a structural homologue of linalool which differs by a methyl-group only. The physical-chemical properties of ethyllinalool are comparable to the two other substances and available experimental data on the same toxicological endpoints, showed identical toxicological properties. Therefore, it is assumed that all toxicological properties are as well comparable and thus read-across is justified.

Acute inhalation toxicity was not tested by standard means. However, there were no deaths at a concentration of 3.2 mg linalool/L and 1.0 mg dehydrolinalool/L. Thus, the LC50s are greater than 3.2 mg linalool/L and 1.0 mg dehydrolinalool/L. Results for ethyllinalool are expected to be very similar.

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: other: no criteria used

Conclusions:

The LC50 was greater than 1.0 mg/L

Executive summary:

All animals survived during 7h the exposure at a nominal concentration of 1 mg/L. Clinical signs consisted of increased breathing rate and snout wiping. No findings were seen at necropsy. The LC50 was greater than 1.0 mg/L.