Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

A Local Lymph Node Assay (LLNA, Remus & Dony, 2016) was performed using three groups of female mice (5 mice per group). The animals were treated with different concentrations of Ethyllinalool (25, 50 (w/v) and 100%) by topical application at the dorsum of each ear once daily on three consecutive days. A control group of five mice was treated with the vehicle (DMF) only. Five days after the first application, the mice were intravenously injected into a tail vein with radiolabelled thymidine, then sacrificed and the lymph nodes were pooled per animal. No relevant increase in ear weights were observed and no relevant erythema was observed. In this study, Stimulation Indicis (S.I.) of 1.7, 3.1, and 4.0 were determined with the test item at concentrations of 25, 50 and 100% in water-free DMF, respectively. A clear dose-response was derived. Ethyllinalool was found to be a skin sensitiser and an EC3 value of 48.2 % (w/v) was derived.

Supporting Human Information: a 30 % Ethyllinalool solution was not sensitising in a Human Maximization Test (RIFM 1975)

The substance is a skin sensitizer (EC3 = 48.2 % w/v).

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available
Additional information:
Migrated from Short description of key information:
Ethyllinalool is not a skin sensitizer and does not carry any of the chemical structural alerts known to be associated with respiratory sensitization. Furthermore, literature data on high exposed factory workers [Schubert HJ (2006) Skin diseases in workers at a perfume factory, Contact Dermatitis: 55: 81–83] or subjects undergoing aromatherapy [Schaller M, Korting HC (1995) Allergic airborne contact dermatitis from essential oils used in aromatherapy, Clinical and Experimental Dermatology 20: 143-145.] showed no indications or clinical signs usually related to respiratory sensitization.

Justification for classification or non-classification

Based on the available information, Ethyllinalool is considered as skin sensitiser. Therefore, the substance Ethyllinalool needs to be classified as sensitizer Cat. 1B according to the critiria outlined in Annex I of Guidance to Regulation (EC) No. 1272/2008 Version 4.1, June 2015.