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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via oral route
Dose descriptor:
365 mg/kg bw/day
Additional information

No data are available for ethyllinalool. However, based on the read across approach to structural similar linalool and dehydrolinalool it is not expected that ethyllinalool is reprotoxic or developmental toxic at doses which are not maternal toxic.

In a reproduction and developmental toxicity screening assay, Coriander oil containing 72.9% linalool was tested. Females were treated with 0, 250, 500, and 1000 mg coriander oil/kg bw/d. The LOEL was 829 mg linalool/kg bw/d. The NOAELs of 365 mg linalool /kg bw/d are based on reduced body weight and food consumption, reduced delivered litter sizes and increased pup mortality when compared to controls. Effects on pups are likely related to maternal toxicity. There was no evidence on adverse effects on female fertility.

In a reproduction/developmental toxicity screening test with dehydrolinalool, a structural comparable substance, dehydrolinalool was administered at 0, 50, 200, and 750 mg/kg bw/d. Basis for NOAEL derivation was mortality, sedation and ataxia in females and hydronephrosis, convoluted and / or hydroureter and retardation in renal and testicular development in pups delivered from dams with delivery complications only. This is likely related to the severe maternal toxicity observed as evident by clinical signs. There was no adverse effect on male and female fertility. The NOAEL for maternal and developmental toxicity was 200 mg/kg bw/d.

Short description of key information:
Reproduction / Developmental Toxicity Screening:
- NOAEL maternal toxicity: 365 mg/kg bw/day (linalool)
- NOAEL developmental toxicity: 365 mg/kg bw/day

Effects on developmental toxicity

Description of key information
Developmental Toxicity Study in rats:
- NOAEL maternal toxicity (linalool): 500 mg/kg bw/day
- NOAEL developmental toxicity (linalool): 1000 mg/kg bw/day
Effect on developmental toxicity: via oral route
Dose descriptor:
1 000 mg/kg bw/day
Additional information

Ethyllinalool, linalool (CAS 78-70-6) and dehydrolinalool (CAS 29717-20-8) are structurally related substances having similar chemical structures. Their physical-chemical properties are comparable and available experimental data on the same toxicological endpoints, showed identical toxicological properties. Therefore the toxicological data on linalool and dehydrolinalool with regard to fertility and developmental toxicity will be used in a read-across approach.

In a developmental toxicity study, linalool was applied to pregnant rats from GD 7 to 17 at 0, 250, 500, 1000 mg/kg bw/d. The NOAEL for maternal toxicity of 500 mg/kg bw/d is based on reduced body weights and food consumption compared to controls. There were no effects on foetuses. Linalool was not teratogenic.

Justification for classification or non-classification

Based on the result that all NOAELs for developmental toxicity are identical to or exceed the NOAELs for maternal toxicity, reproduction and developmental toxicity is not expected. Therefore, it is concluded that ethyllinalool does not need to be classified as toxic to reproduction based on the criteria outlined in Annex I of 1272/2008/EC.

Additional information