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Ecotoxicological information

Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Justification for type of information:
Please refer to the justification for grouping of substances provided in IUCLID Section 13.
Reason / purpose for cross-reference:
read-across source
Key result
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
> 126 mg/L
Nominal / measured:
meas. (arithm. mean)
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
NOEC
Effect conc.:
>= 126 mg/L
Nominal / measured:
meas. (arithm. mean)
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Conclusions:
An LC50 (96 h) of >126 mg/L and a NOEC (96 h) of ≥126 mg/L have been determined for the effects of the source substance on mortality of the fish species Oncorhynchus mykiss in a study according to OECD guideline 203 and GLP. The source substance is the hydrolysis product of the target substance. Since the hydrolysis half life is < 1 h, the results derived for the source substance describe additionally the effects of the the target substance.

Description of key information

LC50 (96 h) >126 mg/L (OECD 203; Oncorhynchus mykiss); read across from hydrolysis product (dimethylsilanediol)

Key value for chemical safety assessment

Additional information

Experimental data for dimethoxydimethylsilane (CAS 1112-39-6) are not available. However, since dimethoxydimethylsilane hydrolyses rapidly to dimethylsilanediol and methanol (DT50 < 0.6 h) the hydrolysis products rather than the parent substance should be considered for the assessment, read-across data for the hydrolysis product, dimethylsilanediol, are considered appropriate for the assessment.The available study with the freshwater fish Oncorhynchus mykiss was performed according to OECD 203 (GLP). Fish were exposed to dimethylsilanediol under static conditions to a nominal limit concentration of 120 mg/L for 96 h (Dow Corning Corporation, 2009a). The concentrations in test solution were verified by HPLC/RID analysis and confirmed that the substance is stable. Since no effects on mortality were recorded the LC50 (96 h) was derived to be > 126 mg/L (measured arithmetic mean).