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EC number: 214-189-4 | CAS number: 1112-39-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 30-08-1988 to 12-09-1988
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: The study was conducted according to the appropriate OECD test guideline, and in compliance with GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Deviations:
- yes
- Remarks:
- Report lacking data on whether clinical examination and physical measurements were conducted.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Dimethoxydimethylsilane
- EC Number:
- 214-189-4
- EC Name:
- Dimethoxydimethylsilane
- Cas Number:
- 1112-39-6
- Molecular formula:
- C4H12O2Si
- IUPAC Name:
- dimethoxydimethylsilane
- Details on test material:
- - Name of test material (as cited in study report): Dimethyldimethoxysilane
- Substance type: Alkoxysilane
- Physical state: A clear liquid
1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Not reported.
- Weight at study initiation: 175-200 g ( Males and Females).
- Housing: The rats were housed in stainless steel, wire mesh bottomed cages of conventional design. At the onset of experiment, the animals were moved into special stainless steel cages. These cages were designed to house the animals during the exposure periods. The animals were returned to their original housing after the exposure period.
- Diet : The animals were fed PURINA Rodent Chow ad libitum except during the exposure period.
- Water : The animals were fed water ad libitum except during the exposure period.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3
- Humidity (%): 30 -50
- Air changes (per hr): 14 - 15 air changes per hour
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: Not reported
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: Exposure was conducted in stainless steel and glass exposure chambers. The chambers were operated under dynamic conditions.
- Exposure chamber volume: 450-litre
- Method of holding animals in test chamber: Not reported.
- Source and rate of air: Airflow rates through the chambers were monitored continuously by calibrated Magnehelic gauges connected across orifices at the chamber inlets.
- Method of conditioning air: Not reported
- System of generating particulates/aerosols: Test material was introduced into the test chamber through a specially designed glass J-tube with a flow FMI Lab pump. Laboratory air filtered with a Matheson 462 cartridge filter passed through the J-tube. The air/vapour mixture entered the top of the chamber where it was diluted with room air. Heating tape was used to heat the air which passed through the J-tube, and glass beads were used to further help vaporize the test material. After the exposure period, the vapour generating equipment was turned off and the vapour concentration in the chamber was allowed to return to zero.
- Method of particle size determination: Not reported.
- Treatment of exhaust air: The exhaust air was filtered (hepa and carbon), cleaned with a water cyclone, then exhausted from the roof of the building.
- Temperature, humidity, pressure in air chamber: Chamber temperature and relative humidity were monitored with Cole-Parmer Model No.3310-40 (certified) temperature and humidity gauges.
TEST ATMOSPHERE
- Brief description of analytical method used: Not reported - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 4 h
- Concentrations:
- The test material target concentration was 5.0 mg/l. The actual nominal chamber concentration was 4.7 mg/l (calculation by weight).
- No. of animals per sex per dose:
- 5 males and 5 females.
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Gauge readings were recorded hourly during the chamber period. Animals were observed once a day during weekdays. Individual animal body weights were taken prior to exposure and on days 7 and 14 after exposure.
- Necropsy of survivors performed: Not reported
- Other examinations performed: body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 4 700 mg/m³ air
- Based on:
- test mat.
- Exp. duration:
- 4 h
- Mortality:
- No mortalities were observed in either groups during the exposure or post-exposure periods.
- Clinical signs:
- other: Not reported.
- Body weight:
- No apparent test material related effect on body weights.
- Gross pathology:
- Not reported.
Any other information on results incl. tables
Table 2. Mortality Data.
Test Material Concentration (mg/l) |
Number of Dead/Number exposed |
|
Males |
Females |
|
0 |
0/5 |
0/5 |
4.7 |
0/5 |
0/5 |
Table 3. Mean Body Weight Data (g).
Days After Exposure |
Group I, Control |
Test Group II |
||
Males |
Females |
Males |
Females |
|
0 |
189 ± 5 |
183 ± 10 |
188 ± 5 |
183 ± 12 |
7 |
242 ± 8 |
214 ± 15 |
248 ± 9 |
205 ± 15 |
14 |
295 ± 13 |
233 ± 21 |
305 ± 15 |
230 ± 20 |
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria are not met, no classification required according to Regulation (EC) No 1272/2008
- Conclusions:
- In an acute inhalation (vapour) study conducted in compliance with OECD 403 and GLP, in which rats were exposed to to >4700 mg/m³ dimethoxydimethylsilane for four hours resulted in no mortality. Therefore, LC50 was determined to be >4700 mg/m³.
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