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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1978
Report date:
1978

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
not specified
Test type:
acute toxic class method

Test material

Constituent 1
Chemical structure
Reference substance name:
Isopropyl chloroformate
EC Number:
203-563-2
EC Name:
Isopropyl chloroformate
Cas Number:
108-23-6
Molecular formula:
C4H7ClO2
IUPAC Name:
propan-2-yl carbonochloridate

Test animals

Species:
rat
Strain:
Wistar
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
0.3163 ml/kg
0.3981 ml/kg
0.5020 ml/kg
0.6310 ml/kg
0.7943 ml/kg
No. of animals per sex per dose:
10
Control animals:
not specified

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
468.3 - 632.4 mg/kg bw
Based on:
test mat.
Sex:
male
Dose descriptor:
approximate LD50
Effect level:
544.2 mg/kg bw
Based on:
test mat.
Mortality:
0.3163 ml/kg
0.3981 ml/kg
0.5020 ml/kg
0.6310 ml/kg
0.7943 ml/kg
Gross pathology:
Injury of gastric mucous membrane.

Applicant's summary and conclusion

Interpretation of results:
sligthly toxic
Remarks:
Migrated information Criteria used for interpretation of results: EU