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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Remarks:
No test article analysis. Non GLP. Non-guideline study design.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1960
Report Date:
1960

Materials and methods

Principles of method if other than guideline:
Groups of 1 rat exposed to 7 concentrations of the test substance. Mortality, clinical signs, and pathology were monitored and an oral ALD was reported.
GLP compliance:
no
Test type:
acute toxic class method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Test substance (as cited in study report): isophthaloyl chloride
Purity: not specified

Test animals

Species:
rat
Strain:
other: ChR
Sex:
male

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
peanut oil
Details on oral exposure:
VEHICLE
25% Solution in Peanut Oil.
Doses:
Single doses of 7500, 5000, 3400, 2250, 1500, 1000, 670 mg/kg
No. of animals per sex per dose:
1
Control animals:
not specified
Details on study design:
No guidelines provided.

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
other: Approximate Lethal Dose (ALD)
Effect level:
5 000 mg/kg bw
Mortality:
1/1 at 7500, 5000 mg/kg
0/1 at 3400, 2250, 1500, 1000, 670 mg/kg
Clinical signs:
Discomfort and found dead following day: 7500, 5000 mg/kg doses
Weight Loss: 3400, 2250 mg/kg
No toxic signs observed: 1500, 1000, 670 mg/kg
Body weight:
Weight loss was observed at doses of 3400 and 2250 mg/kg.
Gross pathology:
Severe Injury to stomach: 7500, 5000 mg/kg doses
No pathological changes: 3400, 2250, 1500, 1000, 370 mg/kg doses

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Approximate Lethal Dose of the test substance was found to be 5000 mg/kg of body weight. Lethal doses caused severe gastritis. Clinical signs of toxicity were not observed in those rats receiving sublethal doses, nor was pathology observed when the rats were killed 10 days later.
Executive summary:

Approximate Lethal Dose of the test substance was found to be 5000 mg/kg of body weight. Lethal doses caused severe gastritis. Clinical signs of toxicity were not observed in those rats receiving sublethal doses, nor was pathology observed when the rats were killed 10 days later.