Registration Dossier
Registration Dossier
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EC number: 240-004-1 | CAS number: 15875-13-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Work pre-dates guidelines and GLPs, Limited documentation, published in peer-reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 974
Materials and methods
- Principles of method if other than guideline:
- Method: other: no data
- GLP compliance:
- no
Test material
- Reference substance name:
- N,N',N''-Tris(dimethylaminopropyl)-s-hexahydrotriazine
- IUPAC Name:
- N,N',N''-Tris(dimethylaminopropyl)-s-hexahydrotriazine
- Reference substance name:
- N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-tripropanamine
- EC Number:
- 240-004-1
- EC Name:
- N,N,N',N',N'',N''-hexamethyl-1,3,5-triazine-1,3,5(2H,4H,6H)-tripropanamine
- Cas Number:
- 15875-13-5
- Molecular formula:
- C18H42N6
- IUPAC Name:
- (3-{3,5-bis[3-(dimethylamino)propyl]-1,3,5-triazinan-1-yl}propyl)dimethylamine
- Details on test material:
- N-N'-N''-Tris(dimethylaminopropyl)-s-hexahydrotriazine, 85% aqueous solution
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 2.02 mL/kg bw
- 95% CL:
- 1.24 - 3.29
- Remarks on result:
- other: Based on a density of 0.912 mg/ml the LD50 would be 1842 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- harmful
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dermal LD50 in rabbits of the 85% aqueous solution is 1842 mg/kg/b.w. The dermal LD50 of the test material is 1566 mg/kg bw.
- Executive summary:
The dermal LD50 in rabbits of the 85% aqueous solution is 1842 mg/kg/b.w. The dermal LD50 of the test material is 1566 mg/kg bw.
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