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Environmental fate & pathways

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General discussion of environmental fate and pathways:

This chemical safety report characterizes the hazards and risks associated with the use ofamides, C16-18(even-numbered) and C18-unsatd., N,N-bis(hydroxyethyl),a diethanolamine-derived fatty acid alkanolamide (“DEA-FAA”) in which fatty acids are bound to diethanolamine (DEA) by an amide bond.The alkyl chain length typically ranges between 16 and 18 carbon atoms.

Grouping hypothesis and justification of read-across adopted

Data for amides, C16-18(even-numbered) and C18 -unsatd., N,N-bis(hydroxyethyl) has been supplemented with safety data from structurally similar fatty acid alkanolamides based on the read-across approach of grouping substances (category approach) and from supporting substances (structural analogue or surrogate) using data from the following DEA-FAA substances:

  • Amides, C8-18(even-numbered) and C18-unsatd., N,N-bis(hydroxyethyl) also called amides, C8-18 and C18-unsatd., N,N-bis(hydroxyethyl)
  • Amides, C12-18(even-numbered) and C18 -unsatd., N,N-bis(hydroxyethyl) also called amides, C12-18 and C18 -unsatd., N,N-bis(hydroxyethyl)
  • Lauric acid diethanolamine condensate (LDEA, CAS No. 120-40-1)
  • Amides, C18-unsatd., N,N-bis(hydroxyethyl)

The grouping hypothesis and therefore the read-across approach adopted are based on the following characteristics of DEA-derived FAA substance:

  • DEA-derived FAA substances all share a common functional group (i.e., fatty acid alkanolamide) and constituents, with only variable carbon range numbers, i.e., the basic structure and functional groups are the same.
  • DEA-derived FAA substances all have common constituents, i.e., incremental and constant change across the category relating to the physical-chemical properties (e.g., melting/boiling point; Kow; Koc; water solubility; environmental distribution characteristics).

The use of data from the “DEA-FAA” category is justified due to structural similarities as indicated by a common functional group (i. e., fatty acid alkanolmide) and comparable fate properties: DEA-FAA are all readily biodegradable and expected to degrade by the same pathways involving omega- and beta oxidation finally leading to complete mineralization.

The structural similarity of “DEA-FAA” results in similar physico-chemical properties such as water solubility and octanol-water partition coefficient as well as similar expected biodegradation pathways.