Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 247-045-4 | CAS number: 25498-49-1
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Short description of key information on bioaccumulation potential result:
A GLP-study equivalent to OECD guideline 417 is available for tripropylene glycol methyl ether. TPGME was rapidly distributed and quickly metabolized and eliminated from animals. TPGME is metabolized extensively. Less than 5 per cent of the high dose was recovered as unchanged TPGME.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 100
- Absorption rate - dermal (%):
- 20
- Absorption rate - inhalation (%):
- 100
Additional information
Both oral and inhalation absorption rates were set at 100%, whereas dermal absorption rate set at 20%. For detailed information, refer to read-across justification document for P-series glycol ethers.
Tripropylene glycol methyl ether (TPGME) was rapidly distributed and quickly metabolized and eliminated from the test animals. Tripropylene glycol, dipropylene glycol and propylene glycol as well as an oxidation product of dipropylene glycol, dipropylene glycol monomethyl ether (DPGME), TPGME and the sulfate conjugate of TPGME were identified in the urine, less than 5 per cent of the high dose was recovered as unchanged TPGME. These results indicate that TPGME is metabolized extensively and is comparable to DPGME in disposition and types of metabolites.
Discussion on bioaccumulation potential result:
Tripropylene glycol methyl ether (TPGME) was rapidly distributed and quickly metabolized and eliminated from the test animals. Tripropylene glycol, dipropylene glycol and propylene glycol as well as an oxidation product of dipropylene glycol, dipropylene glycol monomethyl ether (DPGME), TPGME and the sulfate conjugate of TPGME were identified in the urine, less than 5 per cent of the high dose was recovered as unchanged TPGME. These results indicate that TPGME is metabolozed extensively and is comparable to DPGME in disposition and types of metabolites. Overall, no bioaccumulation potential is expected for TPGME and other glycol ethers.
As a class, the propylene glycol ethers are rapidly absorbed and distributed throughout the body when introduced by inhalation or oral exposure. For detailed information, refer to read-across justification document for P-series glycol ethers. While not tested directly, absorption by inhalation exposure also would be expected to be rapid for PGEs aerosols that are in the respirable range. Dermal absorption is expected to be somewhat slower but, once absorbed, subsequent distribution also should be rapid. Most of the PGE dose would be rapidly excreted. Most excretion for PGEs is via the urine and expired air. A small portion is excreted in the feces.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
