Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-475-4 | CAS number: 107-25-5
Endpoint summary
Administrative data
Description of key information
Data on acute oral toxicity are not available (study technically not feasable; low boiling point).
In acute inhalation studies in rats the LC50 (4h) was > 20165 ppm (48 mg/L).
The LD50 in acute dermal toxicity studies with cold liquid in rabbits was >5000 mg/kg bw.
Key value for chemical safety assessment
Additional information
Oral
Data on acute oral toxicity are not available (study technically not feasable; low boiling point).
Inhalation
No mortality and no clinical signs were found in 10 male and 10 female rats within 14 days after exposure for 4 h to the dose level of 5.3 mg/L (BASF 1980). Also at a dose level of 20165 ppm (48 mg/L) no mortality and no clinical signs were detected in rats exposed for 4 h (post exposure period 14 days (Dow 1990)). In both studies no macroscopic findings were seen at necropsy.
Dermal
No systemic clinical signs and no mortality were reported after 24 h occlusive exposure to 8 mL/kg bw (ca. 5000 mg/kg bw; cold liquid) in two New Zealand White rabbits; the acute dermal LD50 is considered to be > 5000 mg/kg bw (Dow 1990).
Justification for classification or non-classification
Classification for acute toxicity is not warranted according to the criteria of EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
