Registration Dossier

Administrative data

Description of key information

Data on acute oral toxicity are not available (study technically not feasable; low boiling point).
In acute inhalation studies in rats the LC50 (4h) was > 20165 ppm (48 mg/L).
The LD50 in acute dermal toxicity studies with cold liquid in rabbits was >5000 mg/kg bw.

Key value for chemical safety assessment

Additional information

Oral

Data on acute oral toxicity are not available (study technically not feasable; low boiling point).

Inhalation

No mortality and no clinical signs were found in 10 male and 10 female rats within 14 days after exposure for 4 h to the dose level of 5.3 mg/L (BASF 1980). Also at a dose level of 20165 ppm (48 mg/L) no mortality and no clinical signs were detected in rats exposed for 4 h (post exposure period 14 days (Dow 1990)). In both studies no macroscopic findings were seen at necropsy.

Dermal

No systemic clinical signs and no mortality were reported after 24 h occlusive exposure to 8 mL/kg bw (ca. 5000 mg/kg bw; cold liquid) in two New Zealand White rabbits; the acute dermal LD50 is considered to be > 5000 mg/kg bw (Dow 1990).

Justification for classification or non-classification

Classification for acute toxicity is not warranted according to the criteria of EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.