Registration Dossier

Administrative data

Description of key information

Not irritating to the rabbit skin (cold liquid).
Not irritating to the rabbit eye (cold liquid).

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Additional information

In a study on skin irritation of MVE (Dow 1990) there was no erythema, edema, or other irritation in any of 6 New Zealand White rabbits one hour and 1, 2, 3, 7, 10, or 14 days after exposure (occlusive for 4 h) to 0.5 mL of undiluted, cold liquid test substance.

The instillation of 0.1 mL undiluted, cold liquid to the eye resulted only in minor transient conjunctival irritation in 5/6 New Zealand White rabbits 24 h after application; the effects were fully reversible within 24 h (Dow 1990).

Justification for classification or non-classification

Classification for skin or eye irritation is not warranted according to the criteria of EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.