Potassium (R)-(4-hydroxyphenyl)[(3-methoxy-1-methyl-3-oxoprop-1-enyl)amino]acetate

Guidance on Safe Use

First-aid measures

Inhalation: If inhaled, remove to fresh air. -  Ingestion: If swallowed, rinse mouth with water (only if the person is conscious). - Skin contact: rinse with plenty of running water. Remove contaminated clothing and shoes. -Eye contact:  Rinse with plenty of running water.  - In all cases: Obtain medical attention if symptoms occur.

Fire-fighting measures

Small fire suitable: Use dry chemical or CO2. -  Large fire suitable : Use dry chemical powder. alcohol-resistant foam. - Unusual fire/explosion hazards : Fine dust clouds may form explosive mixtures with air. -  Hazardous termal decomposition products : In case of fire, may produce hazardous decomposition products such as carbon monoxide,  carbon dioxide, nitrogen oxides (NO, NO2), ammonia (NH3), amines, potassium oxide. - Special fire-fighting procedures : Fight fire from protected location or maximum possible distance. Keep the area surrounding the fire cool. - Protection of fire-fighters : Wear suitable protective clothing. Self-contained breathing apparatus.

Accidental release measures

Personal precautions : Avoid creating dusty conditions and prevent wind dispersal. Use suitable protective equipment. Keep away from sources of ignition. Take precautionary measures against static discharges. Use explosion-proof electrical (ventilating, lighting and material handling) equipment.- Environmental precautions : Prevent entry into sewers, basements or confined areas. Dyke if necessary. - Clean-up Methods:

Small spill and leak (Vacuum or sweep up material and place in a designated labelled waste container. Clean up affected area with a large amount of water). Large spill and leak (Use explosion-proof electrical - ventilating, lighting and material handling - equipment).

Handling and storage

This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4). Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each manufacturing site.

Written confirmation of application of Strictly Controlled Conditions has been received from every affected Distributor and Downstream Processor/User of the Registrant’s intermediate.

Handling : Use with adequate ventilation. Local exhaust ventilation should be provided. Avoid creating dusty conditions and prevent wind dispersal. Use explosion-proof electrical (ventilating, lighting  and material handling) equipment. Take measures against static discharge. Keep away from sources of ignition. Storage : Store in a fireproof location. Keep away from incompatible materials and avoid specific conditions (Keep away from heat, sparks and flame. Prevent formation of dust clouds). Keep container tightly closed and dry. Keep away from heat and direct sunlight.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:

not regulated

Shipping

SpecialProvisions

Inland waterway transport (UN RTDG/ADN(R))

UN number:

not regulated

Shipping

Remarks

Marine transport (UN RTDG/IMDG)

UN number:

not regulated

Shipping

Remarks

Air transport (UN RTDG/ICAO/IATA)

UN number:

not regulated

Shipping

Remarks

SpecialProvisions

Exposure controls / personal protection

This substance is handled under Strictly Controlled Conditions in accordance with REACH regulation Article 17(3) for on-site isolated intermediates and, in case the substance is transported to other sites for further processing, the substance should be handled at these sites under the Strictly Controlled Conditions as specified in REACH regulation Article 18(4). Site documentation to support safe handling arrangements including the selection of engineering, administrative and personal protective equipment controls in accordance with risk-based management systems is available at each manufacturing site.

Written confirmation of application of Strictly Controlled Conditions has been received from every affected Distributor and Downstream Processor/User of the Registrant’s intermediate.

Engineering measures : Use only with adequate ventilation. Local exhaust ventilation should be provided. Use explosion-proof electrical (ventilating, lighting and material handling) equipment.

Hygiene measures : When using do not eat, drink or smoke. Wash hands after handling compounds and before eating, smoking, using lavatory, and at the end of day.

Personal protective equipment - Production scale  : Respiratory system: Wear dust protection mask P2). Skin and body: Working clothes.

Eyes : Safety glasses with side shields. Hands : Wear suitable gloves (Recommended material (s) : >8 hours (breakthrough time): Nitril rubber, butyl rubber, neoprene, Viton, PVC. Replace damaged gloves).

Advice on personal protection is applicable for high exposure levels.  Select proper personal protection based on a risk assessment of the actual exposure situation.

Stability and reactivity

Stability : Stable under recommended storage and handling conditions.

Conditions to avoid : Keep away from heat, sparks and flame. Prevent formation of dust clouds.

Materials to avoid : No special recommendations.

Hazardous decomposition products : In case of fire:

Keep away from heat, sparks and flame. Prevent formation of dust clouds.

Disposal considerations

Methods of disposal (waste of residues; contaminated packaging). : Waste must be disposed of in accordance with national and local environmental regulations.