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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1990
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Very short description of the test, which is a by-product of an investigation on neurotoxicity of acrylamide derivatives.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1981

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The acute oral toxicity of acrylamide and derivatives, including diacetone acrylamide, in mice was determined using 4 animals per dose level and 4 different doses.
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Reference substance name:
diacetone acrylamide
IUPAC Name:
diacetone acrylamide
Details on test material:
Supplier: Tokyo Kasei Co.

Test animals

Species:
mouse
Strain:
other: ddY
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS- Age at study initiation: 5 - 6 weeks old- Weight at study initiation: 29 +- 2.2 g body weight- Housing: 5 - 7 animals per cage- Diet: laboratory chow, ad libitum- Water: ad libitum

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
physiological saline
Doses:
4 doses.
No. of animals per sex per dose:
4
Control animals:
not specified

Results and discussion

Effect levels
Sex:
male
Dose descriptor:
LD50
Effect level:
7.7 other: mmol/kg
95% CL:
6 - 10
Remarks on result:
other: The LD50, transferred to usual units, is 1303 mg/kg bw.

Applicant's summary and conclusion

Interpretation of results:
harmful
Remarks:
Migrated informationCriteria used for interpretation of results: EU
Conclusions:
The LD50 of diacetone acrylamide to male mice at oral dosing is 1302 mg/kg body weight.
Executive summary:

The LD50 was determined as a by-product of an investigation on neurotoxicity of acrylamide derivatives. The LD50 of diacetone acrylamide to male mice at oral dosing is 1303 mg/kg body weight.