Registration Dossier
Registration Dossier
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EC number: 253-039-2 | CAS number: 36443-68-2
Endpoint summary
Administrative data
Description of key information
Additional information
- With high probability acutely not harmful to aquatic organisms.
- Based on long-term (chronic) toxicity study data, the product is very toxic to aquatic organisms.
- The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriate low concentrations.
Two non-GLP studies are available on the short term toxicity to fish according to OECD guideline 203. No toxic effects occur within the range of water solubility (LC0 and LC50 after 96 h exceed by far water solubility) for rainbow trout. LC50 values for bluegill were calculated to be 43 mg/L. No toxic effects could be recorded in the range of water solubility.
There is one GLP guideline study according to OECD 210 and OECD 23 available on the long-term toxicity to fish in a flow-through system. Body weight was significantly affected at mean measured concentrations of 20 µg/L (LOEC) and higher, while body length reduction was statistically significant at concentrations of 44 µg/L (LOEC) and the highest concentration tested. The NOEC for body weight was 8.8 µg/L, while the NOEC for body length was 20 µg/L.
The short-term toxicity of Daphnia magna of a structural analogue (EC No 255 -392 -8) was studied in a 48 h static test according to OECD 202. No immobilized test organisms were determined during the test period of 48 hours. Thus, the 48 -h EC50 was determined to be at the loading rate of 100 mg/L.
There is one GLP guideline study according to OECD 211 available on the long-term toxicity to invertebrates in a flow-through system. Under the conditions of this study a NOEC for survival of Daphnia magna of 5.5 µg/L after 21 days of exposure (mean measured concentrations) was derived.
To determine the acute toxicity towards aquatic algae two experimental studies are available. In a non-GLP study according to 87/302/EEC, no toxic effects (yield and growth rate) occur within the range of water solubility after 72 h up to the highest tested concentration (100 mg/L nominal).
A second study was conducted according to OECD TG 201 under consideration of GLP and OECD GD 23 for difficult to test substances. A loading rate of 100 mg/L did not reveal any toxic effects and the ErC50 and ErC10 values were determined to be >100 mg/L (nominal), >6.6 mg/L (initial measured).
A respiration inhibition test according to OECD guideline 209 was conducted (CIBA-GEIGY 1988). The IC20, IC50 and IC80 values for respiration inhibition were greater than 100 mg/L.
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