Registration Dossier

Administrative data

Endpoint:
dermal absorption
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
supporting study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Accepted method of estimation for risk assessment

Data source

Reference
Reference Type:
other: Estimate
Title:
Unnamed
Year:
2010

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Estimated using U.S. EPA DERMWIN v1.43a (September 2008)
Principles of method if other than guideline:
The Dermal Permeability Coefficient Program (DERMWIN) estimates the dermal permeability coefficient (Kp) and the dermally absorbed dose per event (DAevent) of organic compounds.
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
CAS No.: 000110-65-6
SMILES : OCC#CCO
CHEM : 2-Butyne-1,4-diol
MOL FOR: C4 H6 O2
MOL WT : 86.09
Radiolabelling:
no

Test animals

Species:
other: Estimate
Strain:
other: Estimate

Administration / exposure

Details on study design:
Log Kow (user-entered): -0.73 (used in Kp calculations)

GENERAL Equation: log Kp = -2.72 + 0.71 log Kow - 0.0061 MW
ALCOHOL Class Equation: log Kp = 0.544 log Kow - 2.884

Results and discussion

Any other information on results incl. tables

GENERAL Equation: Kp (predicted): 1.72e-004 cm/hr

ALCOHOL Class Equation: Kp (predicted): 5.23e-004 cm/hr

Dermally Absorbed Dose per Event:

  Water Conc (mg/cm3): 5.3e+002 (estimated by program)

  Event Duration (hr): 1

  DA(event): 0.092 mg/cm2-event (using Fick's first law)

  DA(event): 0.15 mg/cm2-event (using eqn 5.20 & 5.21)

                  (tau = 0.29 hr, t* = 0.7 hr)

 

Applicant's summary and conclusion