1H-Imidazole-1-ethanol, 4,5-dihydro-, 2-C7-17-alkyl derivs.

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

migrated information: read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

supporting study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Analytical monitoring is missing

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2001

Report date:

2001

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)

Deviations:

no

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

(Z)-2-(8-heptadecenyl)-4,5-dihydro-1H-imidazole-1-ethanol

EC Number:

244-501-4

EC Name:

(Z)-2-(8-heptadecenyl)-4,5-dihydro-1H-imidazole-1-ethanol

Cas Number:

21652-27-7

IUPAC Name:

2-(2-heptadec-8-en-1-yl-4,5-dihydro-1H-imidazol-1-yl)ethanol

Sampling and analysis

Analytical monitoring:

no

Test solutions

Vehicle:

no

Test organisms

Test organisms (species):

Daphnia magna

Study design

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Test conditions

Hardness:

20.8 °dH

Test temperature:

20 °C +/- 1 °C

pH:

8.08-8.28 (initial)
8.21-8.23 (end of test)

Dissolved oxygen:

62.2-63.1 % saturation (initial)
62.8-67.2 % saturation (end of test)

Nominal and measured concentrations:

0.03125, 0.0625, 0.125, 0.25, 0.5, 1 mg/L (nominal concentrations)
No measured concentrations available

Reference substance (positive control):

no

Results and discussion

Effect concentrations

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

0.29 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

mortality

Remarks on result:

other: 95 % CL: 0.26-0.33 mg/L

Applicant's summary and conclusion

Validity criteria fulfilled:

yes

Conclusions:

An EC50 of 0.29 mg/L was determined when Daphnia magna was exposed to (Z)-2-(8-Heptadecenyl)-4,5-dihydro-1H-imidazole-1-ethanol for 48 hours.

Executive summary:

An acute daphnia toxicity study according to OECD Guideloine 202 was carried out with (Z)-2-(8-Heptadecenyl)-4,5-dihydro-1H-imidazole-1-ethanol. An EC50 of 0.29 mg/L was determined.