Registration Dossier
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EC number: 251-932-1 | CAS number: 34316-64-8
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
EC50 > 1000 mg/L for activated sludge; read-across (OECD 209)
Key value for chemical safety assessment
Additional information
Since no studies are available on the microorganism toxicity of dodecanoic acid hexyl ester (CAS No. 34316-64-8), the assessment was based on studies conducted with the structurally most similar category members octyl octanoate (CAS No. 2306 -88 -9) and dodecanoic acid isooctyl ester (CAS No. 84713-06-4) as part of a read across approach. This is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Further justification is given within the endpoint summary 6.1 and within the category justification Section 13. In this case of read-across, the best suited (highest degree of similarity, nearest physico-chemical properties) read-across substances were entered into IUCLID. Nevertheless, as can be seen in the data matrix of the category justification in Section 13, all reliable data in the category support the hazard assessment for this endpoint, by showing a consistent pattern of results.
The key study conducted with octyl octanoate (CAS No. 2306-88-9) was performed according to OECD Guideline 209 (Hammer, 2013). Activated sludge was exposed to the test substance in a static system for 3 hours, at nominal concentrations of 1000, 500, 250, 125 and 62.5 mg/L. No toxicity was observed at any of the concentrations tested, and the EC10 was determined to be > 1000 mg/L.
The key study with dodecanoic acid isooctyl ester (CAS No. 84713-06-4) was performed according to the national guideline DIN 38412, part 8 (van Erp, 1997). A culture of the test organism Pseudomonas putida was exposed to the test substance in a static system for 16 hours, at nominal concentrations of 310, 625, 1250, 2500, 5000 and 10,000 mg/L. No toxicity was observed at any of the concentrations tested, and the EC50 was determined to be > 10,000 mg/L.
Thus, based on theabove mentioned result, and due to the structural and profile similarities of the two substances, as are explained with in the overall endpoint summary 6.1 it can be concluded that the EC50 (nominal) of dodecanoic acid hexyl ester (CAS No. 34316-64-8) is > 100 mg/L.
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