Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-039-3 | CAS number: 102-54-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Biological fate of a representative lipophilic metal compound (ferrocene) deposited by inhalation in the respiratory tract of rats
- Author:
- Dahl AR, Briner TJ
- Year:
- 1 980
- Bibliographic source:
- Toxicol Appl Pharmacol 1980; 56: 232-9
Materials and methods
- Objective of study:
- absorption
- distribution
- Principles of method if other than guideline:
- In a peer reviewed study groups of male and female Fischer 344 rats were exposed (nose-only) to ferrocene vapour labelled with 59Fe and tritium.
The exposure duration was 17 minutes and the average ferrocene concentration was 88 mg/m3 - GLP compliance:
- not specified
Test material
- Reference substance name:
- Ferrocene
- EC Number:
- 203-039-3
- EC Name:
- Ferrocene
- Cas Number:
- 102-54-5
- Molecular formula:
- C10H10Fe
- IUPAC Name:
- iron(2+) dicyclopenta-2,4-dienide
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- 59Fe and tritium
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- 23 male and 22 female rats
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- unchanged (no vehicle)
- Duration and frequency of treatment / exposure:
- 17 minutes
Doses / concentrations
- Dose / conc.:
- 88 mg/m³ air (nominal)
- Control animals:
- yes
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Internal deposition was 61.4 ± 3.7 μg per rat, corresponding to 36.6 ± 2.2% of the total inhaled vapour. Estimated ingestion was 5-25 micrograms. The fate of ingested ferrocene is that it sequests in the liver after passage throught the mucosal barrier of the gastrointestinal tract
- Details on distribution in tissues:
- At the earliest sacrifice time (0hr), 55% of the internally deposited ferrocene was in the nasopharyngeal region, and 30% was in the bronchopulmonary region. The remaining 15% was associated with the gastrointestinal tract or other organs.
Over 75% of the tritium label was excreted within the first day but the 59Fe label largely remained in the bronchopulmonary and nasopharyngeal regions over the duration of the experiment. The remaining 10% of the iron was primarily associated with the liver.
There was a protracted clearance of ferrocene-introduced iron (FII) from the respiratory tract, particulary in the lungs. For the FII remaining after 14 days, half times for clearance of 200 and 70 days can be estimated for the bronohopulmonary and nasopharyngeal regions respectively.
8% of the initially deposited FII was swallowed during or quickly after exposure (fur licking may have contributed to the GI tract FII. Estimated ingestion was 5-25 micrograms. The fate of ingested ferrocene is that it sequests in the liver after passage throught the mucosal barrier of the gastrointestinal tract.
- Details on excretion:
- Of the total initial tritium burden, 75% was excreted in the urine, about 9% was excreted in volatile components and 2% faeces all within 24 hours.
Only 7% of the Fe59 burden was excreted in the urine within the first 48hr. Overall only 15% of Fe59 was excreted by all routes in this period
Metabolite characterisation studies
- Metabolites identified:
- not measured
- Details on metabolites:
- The chemical form of the retained iron was not determined. It was not Ferrocene however as 75% of the tritium label (and correspondingly Cyclopentadiene) was rapidly separated from the ferrocene (24hours)
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results For the FII remaining after 14days, half times for clearance of 200 and 70 days can be estimated for the bronohopulmonary and nasopharyngeal regions respectively.
Internal deposition was 61.4 ± 3.7 μg per rat, corresponding to 36.6 ± 2.2% of the total inhaled vapour. Estimated ingestion was 5-25micrograms. The fate of ingested ferrocene is that it sequests in the liver after passage throught the mucosal barrier of the gastrointestinal tract.
At the earliest sacrifice time (0hr), 55% of the internally deposited ferrocene was in the nasopharyngeal region, and 30% was in the bronchopulmonary region. The remaining 15% was associated with the gastrointestinal tract or other organs.
Over 75% of the tritium label was excreted within the first day but the 59Fe label largely remained in the bronchopulmonary and nasopharyngeal regions over the duration of the experiment. The remaining 10% of the iron was primarily associated with the liver.
There was a protracted clearance of ferrocene-introduced iron (FII) from the respiratory tract, particulary in the lungs. For the FII remaining after 14days, half times for clearance of 200 and 70 days can be estimated for the bronohopulmonary and nasopharyngeal regions respectively.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.