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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

In a peer reviewed study performed to OECD Guideline 401, ferrocene has an oral LD50 1320mg/kg bw (Bingham, 2001).


In a study performed to OECD Guideline 402, ferrocene has a dermal LD50 >3000mg/kg bw (Innospec 1987).


Acute Inhalation studies have been waived based on existing data, exposure considerations and animal welfare.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2001
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
GLP compliance:
not specified
Species:
rat
Strain:
not specified
Sex:
not specified
Route of administration:
oral: unspecified
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 320 mg/kg bw
Interpretation of results:
Category 4 based on GHS criteria
Conclusions:
In a peer reviewed study performed to OECD Guideline 401, ferrocene has an oral LD50 of 1320mg/kg bw
Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
1 320 mg/kg bw
Quality of whole database:
Good peer reviewed study (Klimisch score 2)

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Qualifier:
according to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
GLP compliance:
not specified
Test type:
fixed dose procedure
Species:
rat
Strain:
Wistar
Sex:
male/female
Type of coverage:
occlusive
Vehicle:
other: material wetted
Duration of exposure:
24hours
Doses:
3000 mg/ kg
No. of animals per sex per dose:
5
Control animals:
not specified
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 3 000 mg/kg bw
Sex:
male/female
Dose descriptor:
LD0
Effect level:
3 000 mg/kg bw
Mortality:
There was no deaths at this dosage
Interpretation of results:
GHS criteria not met
Conclusions:
In a study performed to OECD guideline 402, Ferrocene had a dermal LD50>3000mg/kg bw and is not classified by this exposure route
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
3 000 mg/kg bw
Quality of whole database:
Good peer reviewed study (Klimisch score 1)

Additional information

In a study performed to OECD guideline 401, Ferrocene had an LD50 1320mg/kg bw and is classified as harmful by oral exposure

In a study performed to OECD guideline 402, Ferrocene had an NOEC 3000mg/kg bw and is not classified by dermal exposure

Acute Inhalation studies have been waived based on existing data, exposure considerations and animal welfare


Justification for selection of acute toxicity – oral endpoint
Only study available

Justification for selection of acute toxicity – inhalation endpoint
No acute inhalation study is available
Ferrocene is a non-volatile solid and exposure to the material is low during manufacture.
Once manufactured the vast majority of the material is sold as cushions and pellets so exposure to the downstream user is also very low.
Data is available for oral and dermal routes and in the interest of animal welfare this study is waived

Justification for selection of acute toxicity – dermal endpoint
Only one study available

Justification for classification or non-classification

In a study performed to OECD guideline 401, Ferrocene had an LD50 1320mg/kg bw and is classified as Xn;R20 harmful if swallowed (DPD), and acute toxicity category 4; harmful if swallowed (CLP)

In a study performed to OECD guideline 402, Ferrocene had an LD50>3000mg/kg bw and is not classified by dermal exposure

Acute Inhalation studies have been waived based on existing data, exposure considerations and animal welfare. However as the material is harmful by repeat exposure it is advisable to classify as harmful by inhalation for acute exposure too. Therefore it is classified as Xn;R22 harmful if inhaled (DPD), and acute toxicity category 4; harmful by inhalation (CLP)