Registration Dossier

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
other: Case study
Adequacy of study:
supporting study
Study period:
1995
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Short publication

Data source

Reference
Reference Type:
publication
Title:
Occupational contact dermatitis from tosyl chloride in a chemist
Author:
Watsky KL, Reynolds K, Berube D, Bayer FJ
Year:
1995
Bibliographic source:
Contact Dermatitis. 1993 Oct;29(4):211-2.

Materials and methods

Study type:
clinical case study
Endpoint addressed:
skin sensitisation
Principles of method if other than guideline:
Patch testing with tosyl chloride (0.05% and 1% in ethanol)

Test material

Constituent 1
Chemical structure
Reference substance name:
Tosyl chloride
EC Number:
202-684-8
EC Name:
Tosyl chloride
Cas Number:
98-59-9
Molecular formula:
C7H7ClO2S
IUPAC Name:
4-methylbenzenesulfonyl chloride

Results and discussion

Applicant's summary and conclusion

Conclusions:
A case of dermal sensitisation to Tosyl chloride in a chemist is reported.
Executive summary:

Case Report:

A 26-year-old female Indian chemist complained of a several-year history of hand dermatitis dating back to graduate school. While working in the laboratories of a major pharmaceutical company, she had multiple outbreaks of dermatitis which she related to the use of tosyl chloride. She was able to control her condition by using nitrile gloves, but presented for further evaluation and patch testing. None of the other members of her laboratory had dermatitis. The patient had a history of nickel allergy and mild seasonal allergies. There was a family history of allergies to pollen.

Patch testing with the North American standard series and tosyl chloride (0.05% and 1% eth.) gave the following reactions.

 

observation day

D2

D3

D7

cobalt chloride

+

+

 

epoxy resin

+

++

 

nickel sulfate

++

+++

 

tosyl chloride 0.05%

 

?+

+

Tosyl chloride 1%

 

+

 

 

Because the reaction to tosyl chloride might have been irritant, due to conversion to p-toluenesulfonic and hydrochloric acids. patch testing was performed at the workplace. None of 3 co-workers reacted to tosyI chloride (0.05% and I% eth.)