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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

direct observations: clinical cases, poisoning incidents and other
Type of information:
other: Case study
Adequacy of study:
supporting study
Study period:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Short publication

Data source

Reference Type:
Occupational contact dermatitis from tosyl chloride in a chemist
Watsky KL, Reynolds K, Berube D, Bayer FJ
Bibliographic source:
Contact Dermatitis. 1993 Oct;29(4):211-2.

Materials and methods

Study type:
clinical case study
Endpoint addressed:
skin sensitisation
Principles of method if other than guideline:
Patch testing with tosyl chloride (0.05% and 1% in ethanol)

Test material

Constituent 1
Chemical structure
Reference substance name:
Tosyl chloride
EC Number:
EC Name:
Tosyl chloride
Cas Number:
Molecular formula:
4-methylbenzenesulfonyl chloride

Results and discussion

Applicant's summary and conclusion

A case of dermal sensitisation to Tosyl chloride in a chemist is reported.
Executive summary:

Case Report:

A 26-year-old female Indian chemist complained of a several-year history of hand dermatitis dating back to graduate school. While working in the laboratories of a major pharmaceutical company, she had multiple outbreaks of dermatitis which she related to the use of tosyl chloride. She was able to control her condition by using nitrile gloves, but presented for further evaluation and patch testing. None of the other members of her laboratory had dermatitis. The patient had a history of nickel allergy and mild seasonal allergies. There was a family history of allergies to pollen.

Patch testing with the North American standard series and tosyl chloride (0.05% and 1% eth.) gave the following reactions.


observation day




cobalt chloride




epoxy resin




nickel sulfate




tosyl chloride 0.05%




Tosyl chloride 1%





Because the reaction to tosyl chloride might have been irritant, due to conversion to p-toluenesulfonic and hydrochloric acids. patch testing was performed at the workplace. None of 3 co-workers reacted to tosyI chloride (0.05% and I% eth.)