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EC number: 202-684-8 | CAS number: 98-59-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: A 2 page study study report. The study was performed pre-GLP. The study was performed according to a method similar to OECD401.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Very high dose volume. Animals were only observed for signs of intoxication and necropsy was performed on surviving animals.
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Tosyl chloride
- EC Number:
- 202-684-8
- EC Name:
- Tosyl chloride
- Cas Number:
- 98-59-9
- Molecular formula:
- C7H7ClO2S
- IUPAC Name:
- 4-methylbenzenesulfonyl chloride
- Details on test material:
- Name: para-toluene sulphochloride
Appearance: white-coloured crystalline powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- propylene glycol
- Doses:
- 3.00, 3.60, 4.33, 5.18, 6.20 g/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 4 680 mg/kg bw
- 95% CL:
- 4 280 - 5 130
Any other information on results incl. tables
Results:
Within a few hours after dosing the rats showed sluggishness. Later on unconsciousness was frequently observed, especially in the two highest dose groups. Death occurred between 3 hours and 3 days after dosing. Thereafter the survivors recovered gradually and looked quite healthy again at the end of the observation period. Macroscopic examination of the survivors revealed no treatment-related gross alterations.
Dose |
Mortality |
|||
Suspension ml/kg |
Test substance g/kg |
males |
females |
% |
12.0 |
3.00 |
0/5 |
0/5 |
0 |
14.4 |
3.60 |
1/5 |
0/5 |
10 |
17.3 |
4.33 |
2/5 |
1/5 |
30 |
20.7 |
5.18 |
3/5 |
4/5 |
70 |
24.8 |
6.20 |
5/5 |
5/5 |
100 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Remarks:
- Migrated information
- Conclusions:
- The LD50 of para-toluene sulphochloride was calculated to be 4.68 g per kg body weight with 4.28 and 5.13 as the 95 % confidence limits.
Therefore, the test substance can be classified in Category V according to GHS. - Executive summary:
An acute oral toxicity study was performed according to a method similar to OECD401 and pre-GLP. 5 male and 5 female rats were dosed with 3.00, 3.60, 4.33, 5.18 or 6.20 g/kg bw. The animals were observed for signs of intoxication during a 14-day period, after which autopsies were carried out on the survivors. Within a few hours after dosing the rats showed sluggishness. Later on unconsciousness was frequently observed, especially in the two highest dose groups. Death occurred between 3 hours and 3 days after dosing. Thereafter the survivors recovered gradually and looked quite healthy again at the end of the observation period. Macroscopic examination of the survivors revealed no treatment-related gross alterations.The LD50 of para-toluene sulphochloride was calculated to be 4.68 g per kg body weight with 4.28 and 5.13 as the 95 % confidence limits. Therefore, the test substance can be classified in Category V according to GHS.
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