Registration Dossier

Toxicological information

Acute Toxicity: dermal

Currently viewing:

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1976
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Indirect reference: Report of study to EPA as referenced in OECD SIDS dossier on 4-methylbenzenesulfonyl chloride; very limited reporting; no guideline study applying only one animal at three dose levels each.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2003

Materials and methods

Test type:
other: No data

Test material

Constituent 1
Chemical structure
Reference substance name:
Tosyl chloride
EC Number:
202-684-8
EC Name:
Tosyl chloride
Cas Number:
98-59-9
Molecular formula:
C7H7ClO2S
IUPAC Name:
4-methylbenzene-1-sulfonyl chloride
Details on test material:
4-Methylbenzenesulfonyl chloride, Lot No. – QH-5095,
no further data

Test animals

Species:
rabbit
Strain:
New Zealand White
Sex:
male/female
Details on test animals or test system and environmental conditions:
no data

Administration / exposure

Vehicle:
corn oil
Details on dermal exposure:
no data
Duration of exposure:
24 hours
Doses:
3,160, 5,010 and 7,940 mg/kg
No. of animals per sex per dose:
1
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 010 mg/kg bw
Based on:
test mat.
Mortality:
The animals dosed at 3160 mg/kg (1 male) and 5010 mg/kg (1 female) both survived.
One male animal that was dosed at 7940 mg/kg, died within 9 days.
Clinical signs:
Sign of intoxication: reduced appetite and activity (2 - 3 days in survivors). Increased weakness, collapse, death
Gross pathology:
Necropsy: lung hyperomia, liver & kidney discolouration, enlarged gall bladder, gastrointestinal inflammation

Any other information on results incl. tables

Mortality:

Animal No.

Dose

Weight (Ave)

Mortality

Time of mortality

M

F

M

F

Combined

1

3,160

220

 -

 0/1 

 -

 0/1 

9 days

2

5,010

 -

180

 -

 0/1 

 0/1 

3

7,940

210

 -

 1/1 

 -

 1/1 

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
LD50 > 5010 mg/kg.
Executive summary:

Tosyl chloride was applied as a 40% solution-suspension in corn oil on the skin of New Zealand Albino Rabbits for 24 hours. The levels were 3160, 5010 and 7940 mg/kg bw , that were applied to respectively one male, one female and one male animal.

There were some signs of intoxication, consisting of reduced appetite and activity for 2 - 3 days in two survivors that were treated with 3160 and 5010 mg/kg bw. The animal treated with 7940 mg/kg bw showed increased weakness, collapse, and death after 9 days. At necropsy, lung hyperaemia, liver & kidney discolouration, enlarged gall bladder, and gastrointestinal inflammation were observed. The LD50 was concluded to be greater than 5,010 mg/kg.