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EC number: 202-684-8 | CAS number: 98-59-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1976
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Indirect reference: Report of study to EPA as referenced in OECD SIDS dossier on 4-methylbenzenesulfonyl chloride; very limited reporting; no guideline study applying only one animal at three dose levels each.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 003
Materials and methods
- Test type:
- other: No data
Test material
- Reference substance name:
- Tosyl chloride
- EC Number:
- 202-684-8
- EC Name:
- Tosyl chloride
- Cas Number:
- 98-59-9
- Molecular formula:
- C7H7ClO2S
- IUPAC Name:
- 4-methylbenzenesulfonyl chloride
- Details on test material:
- 4-Methylbenzenesulfonyl chloride, Lot No. – QH-5095,
no further data
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- no data
Administration / exposure
- Vehicle:
- corn oil
- Details on dermal exposure:
- no data
- Duration of exposure:
- 24 hours
- Doses:
- 3,160, 5,010 and 7,940 mg/kg
- No. of animals per sex per dose:
- 1
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 010 mg/kg bw
- Based on:
- test mat.
- Mortality:
- The animals dosed at 3160 mg/kg (1 male) and 5010 mg/kg (1 female) both survived.
One male animal that was dosed at 7940 mg/kg, died within 9 days. - Clinical signs:
- Sign of intoxication: reduced appetite and activity (2 - 3 days in survivors). Increased weakness, collapse, death
- Gross pathology:
- Necropsy: lung hyperomia, liver & kidney discolouration, enlarged gall bladder, gastrointestinal inflammation
Any other information on results incl. tables
Mortality:
Animal No. |
Dose |
Weight (Ave) |
Mortality |
Time of mortality |
|||
M |
F |
M |
F |
Combined |
|||
1 |
3,160 |
220 |
- |
0/1 |
- |
0/1 |
9 days |
2 |
5,010 |
- |
180 |
- |
0/1 |
0/1 |
|
3 |
7,940 |
210 |
- |
1/1 |
- |
1/1 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- LD50 > 5010 mg/kg.
- Executive summary:
Tosyl chloride was applied as a 40% solution-suspension in corn oil on the skin of New Zealand Albino Rabbits for 24 hours. The levels were 3160, 5010 and 7940 mg/kg bw , that were applied to respectively one male, one female and one male animal.
There were some signs of intoxication, consisting of reduced appetite and activity for 2 - 3 days in two survivors that were treated with 3160 and 5010 mg/kg bw. The animal treated with 7940 mg/kg bw showed increased weakness, collapse, and death after 9 days. At necropsy, lung hyperaemia, liver & kidney discolouration, enlarged gall bladder, and gastrointestinal inflammation were observed. The LD50 was concluded to be greater than 5,010 mg/kg.
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