Registration Dossier
Registration Dossier
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EC number: 202-547-2 | CAS number: 96-96-8
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- M143
- Author:
- RSC Publishing
- Year:
- 2 011
- Bibliographic source:
- Dictionary of Substances and their effects (DOSE):- Lenga, R. E. (Ed.) Sigma-Aldrich Library of Chemical Safety Data 2nd ed., 1988, 2, 2259, Sigma-Aldrich, Milwaukee, WI, USA.
Materials and methods
- Objective of study:
- absorption
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- DOSE database
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-nitro-p-anisidine
- EC Number:
- 202-547-2
- EC Name:
- 2-nitro-p-anisidine
- Cas Number:
- 96-96-8
- Molecular formula:
- C7H8N2O3
- IUPAC Name:
- 4-methoxy-2-nitroaniline
Constituent 1
- Radiolabelling:
- not specified
Test animals
- Species:
- human
- Sex:
- not specified
Administration / exposure
- Route of administration:
- dermal
- Vehicle:
- unchanged (no vehicle)
Results and discussion
- Preliminary studies:
- Absorption into the body leads to the formation of methaemoglobin, which in sufficient amounts causes cyanosis.
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Absorption into the body leads to the formation of methaemoglobin, which in sufficient amounts causes cyanosis.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
- Executive summary:
Absorption into the body leads to the formation ofmethaemoglobin, which in sufficient amounts causes cyanosis
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