2-nitro-p-anisidine

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Data source

Reference

Reference Type:

review article or handbook

Title:

M143

Author:

RSC Publishing

Year:

2011

Bibliographic source:

Dictionary of Substances and their effects (DOSE):- Lenga, R. E. (Ed.) Sigma-Aldrich Library of Chemical Safety Data 2nd ed., 1988, 2, 2259, Sigma-Aldrich, Milwaukee, WI, USA.

Materials and methods

Objective of study:

absorption

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

DOSE database

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

2-nitro-p-anisidine

EC Number:

202-547-2

EC Name:

2-nitro-p-anisidine

Cas Number:

96-96-8

Molecular formula:

C7H8N2O3

IUPAC Name:

4-methoxy-2-nitroaniline

Radiolabelling:

not specified

Test animals

Species:

human

Sex:

not specified

Administration / exposure

Route of administration:

dermal

Vehicle:

unchanged (no vehicle)

Results and discussion

Preliminary studies:

Absorption into the body leads to the formation of methaemoglobin, which in sufficient amounts causes cyanosis.

Toxicokinetic / pharmacokinetic studies

Details on absorption:

Absorption into the body leads to the formation of methaemoglobin, which in sufficient amounts causes cyanosis.

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information): low bioaccumulation potential based on study results

Executive summary:

Absorption into the body leads to the formation ofmethaemoglobin, which in sufficient amounts causes cyanosis