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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1987
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline study without detailed documentation.

Data source

Reference
Reference Type:
publication
Title:
Skin and eye irritation tests on hexanol
Author:
Jacobs G A, Martens M A
Year:
1987
Bibliographic source:
J. Am .Coll. Toxicol. Acute Toxicity Data 11(6): 722

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Hexan-1-ol
EC Number:
203-852-3
EC Name:
Hexan-1-ol
Cas Number:
111-27-3
Molecular formula:
C6H14O
IUPAC Name:
hexan-1-ol

Test animals

Species:
rabbit
Strain:
New Zealand White

Test system

Type of coverage:
occlusive
Preparation of test site:
not specified
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
undiluted
Duration of treatment / exposure:
4 hour(s)
Observation period:
Examination time points: 1, 24, 48 and 72 hours after end of application
Number of animals:
6

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
24/48/72 h
Score:
2.13
Max. score:
4
Reversibility:
not fully reversible within: 72 hours
Remarks on result:
other: 72 hour score 2.2
Remarks:
Individual animal scores were not presented
Irritation parameter:
edema score
Basis:
mean
Time point:
24/48/72 h
Score:
0.6
Max. score:
4
Reversibility:
fully reversible within: 72 hours
Remarks on result:
no indication of irritation
Remarks:
Individual animal scores were not presented

Any other information on results incl. tables

(individual scores were not reported) Erythema and oedema were observed at 1 hour post-exposure.

Applicant's summary and conclusion

Interpretation of results:
Category 3 (mild irritant) based on GHS criteria
Conclusions:
Based on a group mean 24+48+72 hour erythema score of >2 (2.13) 1-hexanol would be classified as irritant according to EU criteria. Although individual scores are not reported 6 animals were used and it is considered that 1-hexanol will be classified as a mild irritant according to GHS criteria.