Registration Dossier

Administrative data

Link to relevant study record(s)

Description of key information

Key value for chemical safety assessment

Additional information

ADME bis(2-chloroethoxy)methane, CAS 111 -91 -1

Oral:

The highest concentration was found in the kidneys 15 minutes after doing.A peak of elimination was observed at or before the 15 minute time point.In the thymus the 14C concentration increased threefold between 15 minutes and 4 hours and remained constant through 8 hours post dosing. The majority was excreted <24 hours in the urine, only 1.5 % remained in the carcass of rats and mice after 72 hours (Black 2007) .

Dermal:

After dermal exposure to 10 mg/kg bw total dose absorption ranged from 12% to 18% for rats and 14% to 22% for mice in one study (Black 2007) and in another study (RTI 2002) it ranged from 33% to 55% for rats and 17% to 25% for mice. These results indicated that rats, but not mice, ingested a significant amount of bis(2-chloroethoxy)methane from grooming at the administration site. Most of the absorbed dose was excreted in the urine. Up to 50% of the total dose volatilized from the skin of some animals during these 24-hour experiments (Black 2007).

IV:

The substance was rapidly metabolized after IV administration, within 4 hours after dosing the parent chemical was near the limit of detection in blood and not detected in urine.The major metabolite (about 40% of the dose) of BCM in rat and mice was isolated and identified as thiodiglycolic acid. Thiodiglycolic acid is cleared fairly slowly and is highly concentrated in the liver (Black 2007).

Attached is a summary on ADME from NTP TR 536 + proposed metabolic route. Bis(2-chloroethoxy)methaneis rapidly absorbed, distributed and excreted after oral, dermal and IV exposure (Black 2007).