Registration Dossier

Administrative data

Description of key information

The LD50 cut-off of the test item is 200 mg/kg body weight by oral route in the rat. The LD50 is between 50-300 mg/kg bw.

The dermal LD50 of the test item was found to be higher than 2000 mg/kg body weight in male and between 1000 mg/kg body weight and 2000 mg/ kg body weight in female CRL:(WI) rats.

The inhalatory LC50, 4h value of Diformal in Wistar rats was established to be within the range of 0.05 – 0.5 mg/L.

Key value for chemical safety assessment

Additional information

Justification for classification or non-classification

The oral LD50 is between 50-300 mg/kg bw and therefore the test substance is placed in Cat III according to GHS.

The dermal LD50 of the test item was found to be higher than 2000 mg/kg body weight in male and between 1000 mg/kg body weight and 2000 mg/ kg body weight in female CRL:(WI) rats. The test substance is placed in Cat IV according to GHS.

The inhalatory LC50 was established to be within the range of 0.05 – 0.5 mg/L and therefore the test substance is placed in Cat II according to GHS.