Registration Dossier

Administrative data

Description of key information

In vitro studies show  that bis(2-chloroethoxy) methane is neither corrosive nor irritating to skin. In vitro study shows that bis(2-chloroethoxy) methane is not corrosive to the eye. Instillation of diformal into the rabbit eye resulted in slight transient irritation of the conjunctivae completely resolving within 48 hours.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Additional information

Effects on eye irritation: slightly irritating

Justification for classification or non-classification

In vitro studies show that bis(2-chloroethoxy) methane is neither corrosive nor irritating to skin. Instillation of bis(2-chloroethoxy) methane into the rabbit eye resulted in slight transient irritation of the conjunctivae completely resolving within 48 hours. Therefore the substance is not classified.