Hexahydro-1,3,5-trimethyl-1,3,5-triazine

Partition coefficient

Link to relevant study record(s)

Reference

Endpoint:

partition coefficient

Type of information:

experimental study

Adequacy of study:

key study

Study period:

07 March 2007 to 15 March 2007

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

HPLC method

Partition coefficient type:

octanol-water

Analytical method:

high-performance liquid chromatography

Key result

Type:

log Pow

Partition coefficient:

0.76

Remarks on result:

other: Temperature & pH not reported

Details on results:

Three peaks were detected with UV and one with RI. Table 1 gives the individual retention times for each component and the calculated log n-octanol/water partition coefficient, relative to the reference compounds.

Table 1: Log Pow values for the test item

Sample	Detector	Retention time (mins)		Peak area (%)		Log Pow
		Run 1	Run 2	Run 1	Run 2	Run 1	Run 2
Peak 1	UV	2.758	2.76	0.76	0.78	-2.57	-2.55
	RI	-	-	-	-	-	-
Peak 2	UV	3.207	3.193	0.47	0.52	-0.43	-0.47
	RI	-	-	-	-	-	-
Peak 3	UV	3.779	3.776	98.77	98.70	0.61	0.61
	RI	3.898	3.889	100.0	100.0	0.76	0.75

Conclusions:

These results show all peaks have log Pow values less than 3.0 and are consistent with a material that has little tendency to accumulate in the environment. The log Pow of hexahydro-1,3,5-trimethyl-1,3,5-triazine was 0.76 and the log Pow of the impurities ranged from -2.57 to -0.47.

Executive summary:

Substances under test: Hexahydro-1,3,5 -trimethyl-1,3,5 -triazine

Chemex reference: Sample - ECO020727. Study - ENV8008

Test type: Partition coefficient (n-octanol/ water) by HPLC

Test conditions: Partition coefficient (n-octanol/ water) according to OECD Guidelines for the Testing of Chemicals reference 117.

Test dates: 07 March 2007 - 15 March 2007

Test carried out at:

Chemex Environmental International Limited

Unit J

Broad Lane Industrial Estate

Cottenham

Cambridge

CB24 8SW

England

Results:

Sample	Detector	Peak area (%)		Log Pow
		Run 1	Run 2	Run 1	Run 2
Peak 1	UV	0.76	0.78	-2.57	-2.55
	RI	-	-	-	-
Peak 2	UV	0.47	0.52	-0.43	-0.47
	RI	-	-	-	-
Peak 3	UV	98.77	98.70	0.61	0.61
	RI	100.0	100.0	0.76	0.75

Three peaks were detected with UV and one with RI. These results show all peaks have log Pow values less than 3.0 and are consistent with a material that has little tendency to accumulate in the environment. The log Pow of hexahydro-1,3,5-trimethyl-1,3,5-triazine was 0.76 and the log Pow of the impurities ranged from -2.57 to -0.47.

Description of key information

Log Pow = 0.76, OECD 117, Staniland (2007)

Key value for chemical safety assessment

Log Kow (Log Pow):

0.76

Additional information

A single key study was submitted for this endpoint, conducted in accordance with OECD Guideline 117. The n-octanol/water partition coefficient (P_ow) was determined to be 5.75 (log P_ow = 0.76) (Staniland 2007).