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EC number: 931-228-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January and February 1979
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study based on national and scientific standards, basic data given, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: SOP No. CT20-137, version 01 (ICI)
- Principles of method if other than guideline:
- reduced exposure time, below 4 h
- GLP compliance:
- no
Test material
- Reference substance name:
- Amines, C12-18-alkyl
- EC Number:
- 268-953-7
- EC Name:
- Amines, C12-18-alkyl
- Cas Number:
- 68155-27-1
- Molecular formula:
- mixture of C13 [C13H29N] and C15 [C15H33N]-branched and linear amines
- IUPAC Name:
- Amines, C12-18-alkyl
- Test material form:
- liquid
- Details on test material:
- - Name of test material (as cited in study report): Synprolam 35 (trade name)
- Substance type: organic
- Physical state: liquid, clear
- Melting point: 12.5 °C
- Boiling point: 263 °C
- Density: 0.806 g/mL (20 °C)
- Analytical purity: no data
- Impurities (identity and concentrations): no data
- Composition of test material, percentage of components: no data in the Report
data adopted from the precursor aldehyde mixture (SYNPRAL 135):
- n-tridecylamine 33 % (m/m)
- isotridecylamine 33 % (m/m)
- n-pentyldecylamine 14 % (m/m)
- isopentylamine 14 % (m/m)
- other components 6 % (m/m)
[Reference: ICI 1975/1976: Synthetic fatty amines - Synpral 135 (Synprolaldehyde; C13/C15 alkyl aldehyde). MSDS]
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: shaved, intact and abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 1 h and 3 min
- Observation period:
- 1, 4, 24, 48, and 96 h (after 1-h exposure),
4, 24, 48, and 72 h (after 3-min exposure) - Number of animals:
- 6 each
- Details on study design:
- no data
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Remarks:
- necrosis
- Basis:
- other: 2/6 animals (1-h exposure)
- Time point:
- other: 4 h p.a.
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: corrosive: => not quantitively evaluable, descriptive rating: Scores are surrogates.
- Irritation parameter:
- overall irritation score
- Remarks:
- necrosis
- Basis:
- other: 6/6 animals (1-h exposure)
- Time point:
- other: 24, 48, and 96 h p.a.
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: corrosive: => not quantitively evaluable, descriptive rating: Scores are surrogates.
- Irritation parameter:
- overall irritation score
- Remarks:
- necrosis
- Basis:
- other: 5/6 animals (3-min exposure)
- Time point:
- other: 4 h p.a.
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: corrosive: => not quantitively evaluable, descriptive rating: Scores are surrogates.
- Irritation parameter:
- overall irritation score
- Remarks:
- necrosis
- Basis:
- other: 6/6 animals (3-min exposure)
- Time point:
- other: 24, 48, and 72 h p.a.
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- other: corrosive: => not quantitively evaluable, descriptive rating: Scores are surrogates.
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Remarks:
- Due to the corrosivity no erythema score could be derived.
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Remarks:
- Due to the corrosivity no erythema score could be derived.
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Remarks:
- Due to the corrosivity no erythema score could be derived.
- Irritation parameter:
- erythema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Remarks:
- Due to the corrosivity no erythema score could be derived.
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Remarks:
- Due to the corrosivity no erythema score could be derived.
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Remarks:
- Due to the corrosivity no erythema score could be derived.
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Remarks:
- Due to the corrosivity no edema score could be derived.
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Remarks:
- Due to the corrosivity no edema score could be derived.
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Remarks:
- Due to the corrosivity no edema score could be derived.
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Remarks:
- Due to the corrosivity no edema score could be derived.
- Irritation parameter:
- edema score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Remarks:
- Due to the corrosivity no edema score could be derived.
- Irritation parameter:
- edema score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Remarks on result:
- not determinable
- Remarks:
- Due to the corrosivity no edema score could be derived.
- Irritant / corrosive response data:
- After exposure of 1 h, tissue destruction was observed in 2/6 animals after 4 h post-application and in all animals at 24 through 96 h It was characterised by thickened, dark, necrotic skin with slight hardening and surrounded by an area of blanched skin edged with erythematous skin.
After exposure of 3 min, similar signs of tissue destruction were observed 4 h post-application.
Any other information on results incl. tables
Observations after 3 -minute application:
Test Site | Ratio of 6 Rabbits | ||||
4 hr | 24 hr | 48 hr | 96 hr | ||
Abraded | 5/6 | 6/6 | 6/6 | 6/6 | |
Intact | 5/6 | 6/6 | 6/6 | 6/6 |
Observations after 1 -hour application:
Test Site | Ratio of 6 Rabbits | ||||
1 hr | 4 hr | 24 hr | 48 hr | 96 hr | |
Abraded | 0/6 | 2/6 | 6/6 | 6/6 | 6/6 |
Intact | 0/6 | 2/6 | 6/6 | 6/6 | 6/6 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 1A (corrosive) based on GHS criteria
- Conclusions:
- The test item caused corrosive responses under the conditions of this test.
- Executive summary:
The effect of the test item on rabbit skin was assesed in oder to classify the potential corrosivity according to standard operating procedure no. CT20 -137, Version 01.
In a first study, the test item was applied for one hour on abraded and intact skin of six rabbits, respectivetly. Tissue destruction was observed in two out of six animals at 4 hours and in all six animals at 24 hours after application. It was characterised by thickened, dark, necrotic skin with slight hardening and surrounded by an area of blanched skin edged with erythematous skin.
Similar signs of tissue destruction were observed 4 hours after a 3 -minute application of the test item.
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