Registration Dossier
Registration Dossier
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EC number: 211-334-3 | CAS number: 638-38-0
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Manganese (II) actetate has a low potential for bioaccumulation, which is only due to the Mn2+ cation. Manganese is a required trace element and acetate is a common metabolite in many metabolic pathways.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
Additional information
In order to assess the toxicological behaviour of Manganese (II) acetate, the available physico-chemical and toxicological data have been evaluated. The substance is expected to be well absorbed after oral exposure. Concerning the absorption after exposure via inhalation, as the chemical has a really low vapour pressure, a decomposition temperature and is furthermore distributed as aqueous solution; it is clear, that the substance has a low availability for inhalation. However, in case inhalable dusts are formed by the less present water-free salt, inhalative absorption has to be considered. The substance has only a low bioaccumulative potential, which is only due to the manganese cation. Its absorption during normal environmental or slightly elevated exposure does not bear any potential for adverse effects, because Manganese is also a required trace element to maintain the normal functionality of the body and acetate is a common metabolite in many metabolic pathways.
The present expert statement covers all relevant toxicokinetic parameters to assess the behaviour of manganese (II) acetate (Mn(acO)2) in the body, the available information is sufficient to enable one to perform a proper risk assessment. Hence, no further information needs to be gathered, all data requirements under REACH are fulfilled and further studies can be omitted due to animal welfare. In conclusion, Mn(acO)2 has only a low potential for bioaccumulation, and its absorption during normal environmental or slightly elevated exposure does not bear any potential for adverse effects but is also required to maintain the normal functionality of the body.
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