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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Data derived from IUCLID 4 dataset of Potassium acetate, which can be freely downloaded from the EINECS search page (http://esis.jrc.ec.europa.eu/). Only basic data given, no further information can be retrieved.

Data source

Reference
Reference Type:
secondary source
Title:
Unnamed
Year:
2000
Report date:
1981

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
not specified
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Potassium acetate
EC Number:
204-822-2
EC Name:
Potassium acetate
Cas Number:
127-08-2
Molecular formula:
C2H4O2.K
IUPAC Name:
potassium acetate
Test material form:
other: commercial formulation
Details on test material:
- Name of test material (as cited in study report): potassium acetate.
- Substance type: commercial formulation
- Physical state: liquid

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
no data

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
no data
Duration of treatment / exposure:
no data
Observation period:
no data
Number of animals:
no data
Details on study design:
no data

Results and discussion

In vivo

Results
Remarks on result:
other: No details on "Irritation parameter", "Time point" and "Score"; however, the available information is nevertheless considered to be sufficient to cover this endpoint.
Irritant / corrosive response data:
not irritating

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: not specified
Conclusions:
It was concluded that Potassium acetate is not irritating. Although the reliability of the study cannot be assessed due to lacking data, the results are in congruence with a scientifically expected outcome. Potassium acetate does not need to be classified as skin irritant, and since it serves as a read-across substance for Manganese (II) acetate, the latter does not need to be classified, too.
Executive summary:

In a OECD 404 guideline study, a commercial formulation of potassium acetate was tested in rabbits for its skin irritating potency. Potassium acetate was not irritating to the rabbit skin, and since it serves as a read-across substance for Manganese (II) acetate, the latter does not need to be classified as skin irritant, too.