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EC number: 209-400-1 | CAS number: 576-26-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted in methods comparable to OECD guideline 404. However, animals were only observed immediately after patch removal and at 72 hours.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 965
- Report date:
- 1965
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- Animals were observed immediately after patch removal and at 72 hours.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,6 xylenol
- IUPAC Name:
- 2,6 xylenol
- Reference substance name:
- 2,6-xylenol
- EC Number:
- 209-400-1
- EC Name:
- 2,6-xylenol
- Cas Number:
- 576-26-1
- Molecular formula:
- C8H10O
- IUPAC Name:
- 2,6-dimethylphenol
- Details on test material:
- - Name of test material (as cited in study report): 2,6-xylenol
- Physical state: white solid
- Analytical purity: The material was considered to be free of impurities.
- Other: received on April 19, 1965. The test substance has a pungent odor.
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.1 to 2.7 kg.
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: both intact and abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Untreated skin areas were used as control.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: The test substance was moistened with a small amount of water and applied to six one-inch square patches in the amount of 0.5 grams per patch. - Duration of treatment / exposure:
- 24 hours
- Observation period:
- The test sites were observed for irritation 24 and 72 hours after application.
- Number of animals:
- Six animals were divided into two groups, three with intact and the remaining three with abraded skin.
- Details on study design:
- TEST SITE
- Area of exposure: designated area on the denuded back
- Type of wrap if used: The trunk of each animal was wrapped with rubberized cloth to keep the patches in place and retard any evaporation of the test substance.
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: Following an exposure period of 24 hours, the binders and patches were removed.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24
- Score:
- > 1
- Reversibility:
- other: not reported
- Remarks on result:
- other: A necrotizing effect was noted at all time points; no dermal irritation score was reported.
- Irritant / corrosive response data:
- Necrosis was noted on all of the intact and abraded areas at 24 and 72 hours post exposure. The necrotizing effect of the test substance precluded any accurate readings for erythema; therefore it was not possible to determine the primary irritation index of the test substance. Slight to marked edema was observed in most or all exposed sites at each of the observation intervals.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (corrosive)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- A single application of 0.5 grams of 2,6-xylenol to the intact and abraded rabbit skin by a 24-hour patch test produced necrosis and edema on all exposed areas at 24 and 72 hours after application. The test substance was considered to be corrosive and irritating to the skin.
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