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Environmental fate & pathways

Bioaccumulation: aquatic / sediment

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Reference
Endpoint:
bioaccumulation in aquatic species: fish
Type of information:
(Q)SAR
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
Justification for type of information:
The QMRF and QPRF documents are attached to "Background information".
Qualifier:
according to
Guideline:
other: REACH guidance on QSARs, R.6, May 2008
Principles of method if other than guideline:
QSAR based on partiotioning between fat and water.
GLP compliance:
no
Type:
BCF
Value:
ca. 70 L/kg
Remarks on result:
other: QSAR calculation (BCFBAF v3.01)
Details on results:
See attached QPRF and QMRF files.
Validity criteria fulfilled:
yes
Remarks:
Ethylhexyl-(S)-lactate is considered to be within the applicability domain of the BCFBAF v3.01 model.
Conclusions:
With a bioconcentration factor for fish of approximately 70 (estimated by QSAR), ethylhexyl-(S)-lactate is not liable to bioconcentrate.
Executive summary:

With a bioconcentration factor for fish of approximately 70 (estimated by QSAR), ethylhexyl-(S)-lactate is not liable to bioconcentrate.

Description of key information

The QSAR calculated BCF for fish of 70 suggests that 2-ethylhexyl-S-lactate exhibits only a minor bioaccumulation potential.

Key value for chemical safety assessment

BCF (aquatic species):
70 L/kg ww

Additional information

2-ethylhexyl-S-lactate is not liable to bioaccumulate.