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EC number: 255-280-9 | CAS number: 41253-21-8
- Life Cycle description
- Uses advised against
- Endpoint summary
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- Density
- Particle size distribution (Granulometry)
- Vapour pressure
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- Endpoint summary
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- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From Jul. 13, 1992 to Aug. 11, 1992
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study (OECD 405). No GLP study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1H-1,2,4-triazole, sodium salt
- EC Number:
- 255-280-9
- EC Name:
- 1H-1,2,4-triazole, sodium salt
- Cas Number:
- 41253-21-8
- Molecular formula:
- C2H3N3.Na
- IUPAC Name:
- sodium 1,2,4-triazol-1-ide
- Details on test material:
- - Name of test material (as cited in study report): 1,2,4 - Triazole, sodium salt
- Physical state: solid (powder)
- Analytical purity: =99%
- Lot/batch No.: 92/492
- Storage condition of test material: room temperature, away from light
-Expiration date of lot/batch: after 1995
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: COB.LABO.LAP farm at 22120 YFFINIAC (FRANCE)
- Age at study initiation: Not reported
- Weight at study initiation: 2.5 g
- Housing: Individual housing on floor grid
- Diet (e.g. ad libitum): Not reported
- Water (e.g. ad libitum): Not reported
- Acclimation period: at least 1 week
ENVIRONMENTAL CONDITIONS: in accordance with the requirements of the 86/609/EEC
- Temperature (°C): Not reported
- Humidity (%): Not reported
- Air changes (per hr): Not reported
- Photoperiod (hrs dark / hrs light):Not reported
IN-LIFE DATES: From: July 13, 1992 To: July 16, 1992
Test system
- Vehicle:
- water
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL (~80 mg) - Duration of treatment / exposure:
- single exposure
- Observation period (in vivo):
- for 72 hours
- Number of animals or in vitro replicates:
- 1 animal
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): no
- Time after start of exposure: Not applicable
SCORING SYSTEM: Draize criteria
TOOL USED TO ASSESS SCORE: fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- other: 1h
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within 72 hours
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- ca. 3
- Max. score:
- 3
- Reversibility:
- not reversible
- Remarks:
- within 72 hours
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- other: 1h
- Score:
- ca. 2
- Max. score:
- 2
- Reversibility:
- not reversible
- Remarks:
- within 72 hours
- Irritation parameter:
- cornea opacity score
- Remarks:
- Opacity
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within 72 hours
- Irritation parameter:
- cornea opacity score
- Remarks:
- surface of corneal opaqueness
- Basis:
- animal #1
- Time point:
- other: 1 hour
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- withing 72 hours
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within 72 hours
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- ca. 3
- Max. score:
- 3
- Reversibility:
- not reversible
- Remarks:
- within 72 hours
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- ca. 2
- Max. score:
- 2
- Reversibility:
- not reversible
- Remarks:
- within 72 hours
- Irritation parameter:
- cornea opacity score
- Remarks:
- Opacity
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within 72 hours
- Irritation parameter:
- cornea opacity score
- Remarks:
- surface corneal opaqueness
- Basis:
- animal #1
- Time point:
- 24 h
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within 72 hours
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within 72 hours
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- ca. 3
- Max. score:
- 3
- Reversibility:
- not reversible
- Remarks:
- within 72 hours
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- ca. 2
- Max. score:
- 2
- Reversibility:
- not reversible
- Remarks:
- within 72 hours
- Irritation parameter:
- cornea opacity score
- Remarks:
- Opacity
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within 72 hours
- Irritation parameter:
- cornea opacity score
- Remarks:
- surface corneal opaqueness
- Basis:
- animal #1
- Time point:
- 48 h
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within 72 hours
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- ca. 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within 72 hours
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- ca. 3
- Max. score:
- 3
- Reversibility:
- not reversible
- Remarks:
- within 72 hours
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- ca. 2
- Max. score:
- 2
- Reversibility:
- not reversible
- Remarks:
- within 72 hours
- Irritation parameter:
- cornea opacity score
- Remarks:
- Opacity
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within 72 hours
- Irritation parameter:
- cornea opacity score
- Remarks:
- surface corneal opaqueness
- Basis:
- animal #1
- Time point:
- 72 h
- Score:
- ca. 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- within 72 hours
- Irritant / corrosive response data:
- Important and non reversible irritation reactions are observed on the rabbit's treated eye:
1. to the level of the conjunctiva: tumefaction with eyelids more than half closed and intense hyperhemia.
2. iris discernible with difficulty, absence of reaction to light, important haemorrhage visible.
3. opacity in the whole area of the cornea on all surface. - Other effects:
- no
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Executive summary:
One eye of one rabbit was exposed 80 mg of 1,2,4-Triazole sodium salt according to the OECD 405 guideline. The substance caused serious eye damage, and these phenomena were not reversible in 72 hours. Each scores were estimated according to the criteria of Draize. For each item, at each time, the score was the maximal score. According CLP criteria, the susbtance is classified as category 1 (irreversible effects on the eye).
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