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EC number: 255-280-9
CAS number: 41253-21-8
1,2,4-triazole produced considerable evidence of toxicity in
P-generation animals at a dietary level of 3,000 ppm (188.6 and 217.9
mg/kg/day for males and females, respectively), including reduced
fertility and neuropathology. By comparison, the only evidence of
toxicity at lower dietary levels of 250 and 500 ppm was slightly reduced
body weight in Fr-generation males. Based on these results, the
reproductive (fertility) NOAEL is 34.4 mg/kg/day and the LOAEL is 231.7
mg/kg/day, based on findings in P-generation animals. The developmental
NOAEL is 35.8 mg/kg/day and the LOAEL is greater than 35.8 mg/kg/day. No
definitive parental NOAEL was established, a slight decrease in body
weight in the F1-generation males was observed at 16.0 mg/kg/day (250
ppm), but these findings were minor, seen only in males of one
generation and not reported from any other available study at this
level. For females, the parental NOAEL was demonstrated to be 36.2
mg/kg/day (500-ppm). These results, including an extensive investigation
of brain morphology, provided no evidence of developmental neurotoxicity
at a dietary level of 500-ppm.
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