Isobutyl acrylate

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

experimental study

Adequacy of study:

other information

Study period:

January 1987 - April 1992 (guerra et al.); January 1984 - May 1992 (Tosti et al.)

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Prevalence and sources of occupational contact sensitization to acrylates in Italy.

Author:

Guerra L et al.

Year:

1993

Bibliographic source:

Contact Dermatitis 28: 101-103

Reference 2

Reference Type:

publication

Title:

Occupational Skin Hazards from Synthetic Plastics.

Author:

Tosti A et al.

Year:

1993

Bibliographic source:

Toxicol. Ind. Health 9: 493-502

Materials and methods

Type of study / information:

Type of experience: Human

Endpoint addressed:

skin sensitisation

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

82 patients suspected of occupational acrylic sensitization were patch tested with the GIRDCA standard series (Hermal-Trolab, Bracco-Milan) and an extensive acrylate series, supplied by Firma S.p.A . (Florence)

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Isobutyl acrylate

EC Number:

203-417-8

EC Name:

Isobutyl acrylate

Cas Number:

106-63-8

Molecular formula:

C7H12O2

IUPAC Name:

isobutyl acrylate

Method

Ethical approval:

not specified

Details on study design:

Patients were patch-tested with 5 % of isobutyl acrylate dissolved in petrolatum.

Results and discussion

Any other information on results incl. tables

Guerra et al: Between January 1987 and April 1992, 82 patients suspected of occupational acrylic sensitization were patch tested with standard series and an extensive acrylate series, including isobutyl acrylate (5 % in petrolatum). No positive patch test reaction to isobutyl acrylate was reported in this group of patients. Detailed results for all acrylates used were not provided.

 

Tosti et al.: January 1984 to May 1992, 39 cases of occupational allergic contact dermatitis to epoxy resin system substances were detected. An allergic airborne contact dermatitis was present in 25 patients. Thirty patients showed positive patch test reaction resin, whereas 9 patients showed isolated sensitizations to reactive diluents and/or hardeners.

 

Eighteen of the 39 patients affected by occupational contact dermatitis due to epoxy resins were employed in the electronics industry. Ten of these 16 patients worked in the same electromechanical factory producing condensers for radio and television sets. Three workers were involved in the manufacture of fiberglass fishing-rods and developed an airborne contact dermatitis due to textile fibre dusts. No positive patch test reaction to isobutyl acrylate was reported in this manuscript. Detailed results of the investigated patch tests were not provided.