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Diss Factsheets
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EC number: 203-417-8 | CAS number: 106-63-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 968
- Report date:
- 1968
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 991
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Six rats per dose group were exposed to isobutyl acrylate vapours at metered concentrations (not checked analytically) of 1000, 2000 and 4000 ppm (corresponding to approx. 5.2, 10.5 and 21 mg/L) in a 9 liter glass exposure chamber for 4 h. The animals were observed for 14 days and the LC50 was calculated by the moving average method based on a 14-day observation period.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Isobutyl acrylate
- EC Number:
- 203-417-8
- EC Name:
- Isobutyl acrylate
- Cas Number:
- 106-63-8
- Molecular formula:
- C7H12O2
- IUPAC Name:
- isobutyl acrylate
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: Isobutyl acrylate
- Physical state: liquid
- Lot/batch No.: 02497
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Fasting period before study: none
- Diet: Rockland diets (ad libitum)
- Water: ad libitum
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
Vapours at metered concentrations, not checked analytically, were generated by feeding the liquid at a constant rate down the inside of a spirally corrugated surface of a minimally heated one inch Pyrex tube, through which metered air was passed. Resultant vapours were delivered to rats in a 9-liter glass exposure chamber. - Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- 1000, 2000, 4000 ppm (corresponding to approximately 5.2, 10.5, 21 mg/L) Calculation of concentrations (mg/L) based on Derelanko MJ (2000). Toxicologist's Pocket Handbook, CRC Press, conversion table, p. 57.
- No. of animals per sex per dose:
- 6
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, gross pathology
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- ca. 10.5 mg/L air
- Based on:
- test mat.
- 95% CL:
- > 7.4 - < 14.8
- Exp. duration:
- 4 h
- Mortality:
- No mortality was observed in 1000 ppm dose group; 3/6 animals died in 2000 ppm dose group at days 4,5,6 after exposure; all animals died in 4000 ppm dose group on the day of exposure.
- Clinical signs:
- other: 1000 ppm dose group: extremities irritated at 3 h of exposure; 2000 ppm dose group: eyes and noses irritated at 1 h of exposure, and gasping at 3 h of exposure; 4000 ppm dose group: Rubbing noses and keeping eyes closed immmediately, hyperactive at 30 min
- Gross pathology:
- Abnormalities observed through necropsy included capillary injection on all animals at the highest dose group. Consolidation of the lungs in 3 animals in the middle dose group. Nothing remarkable in the surviving animals.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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