Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

Currently viewing:

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1962
Report date:
1962

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
BASF Test following internal SOP
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Isobutyl acrylate
EC Number:
203-417-8
EC Name:
Isobutyl acrylate
Cas Number:
106-63-8
Molecular formula:
C7H12O2
IUPAC Name:
isobutyl acrylate
Specific details on test material used for the study:
- Name of test material: Isobutylacrylate stabilised with 0.006 % Hydrochinonmonomethylether

Test animals

Species:
mouse
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
other: 20%, 8%, 4%, 2% aqueous emulsion with traganth
Details on exposure:
single intraperitoneal injection
Doses:
200, 250, 320, 500, 800, 1600 mg/kg bw
No. of animals per sex per dose:
10 animals; 200 mg/kg bw dosing group only 5 animals
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations: daily on working days
- Frequency of weighing: prior to dosing
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 400 mg/kg bw
Based on:
test mat.
Mortality:
LD50 0.45 mL/kg (tested as 8% aqueous emulsion in traganth)
200 mg/kg dosing group: 1/5 (48 hours); 1/5 in total
250 mg/kg dosing group: 3/10 (7 days); 4/10 in total
320 mg/kg dosing group: 1/10 (48 hours); 4/10 in total
400 mg/kg dosing group: 1/10 (48 hours); 4/10 (7 days); 4/10 in total
500 mg/kg dosing group: 1/10 (48 hours); 6/10 (7 days); 6/10 in total
800 mg/kg dosing group: 6/10 (24 hours); 7/10 (48 hours); 10/10 (7 days); 10/10 in total
1600 mg/kg dosing group: 9/10 (24 hours); 9/10 (48 hours); 9/10 (7 days); [14 day observation missing]
Clinical signs:
narcosis, staggering, apathy, accelerated respiration; lateral position, late deaths;
following days: apathy, ruffled coat; symptomes decreased till the end of the observation period
Gross pathology:
survivers: organs without findings;
deceased animals: enteritis in one animal; irritation of the peritoneum with some local adhesions in 1 animal

Applicant's summary and conclusion