Registration Dossier

Administrative data

Endpoint:
neurotoxicity: acute oral
Type of information:
experimental study
Adequacy of study:
other information

Data source

Reference
Reference Type:
other: microfiche
Title:
Cyclohexylamine: CNS studies
Author:
Air Prods & Chem Inc
Year:
1987
Bibliographic source:
EPA/OTS0540890
Report date:
1968

Materials and methods

Principles of method if other than guideline:
1. mouse symptomatology-toxicity
2. antidepressant suties in mice
3. EEG studies in rabbits
GLP compliance:
no
Limit test:
no

Test material

Constituent 1
Reference substance name:
Cyclohexylammonium chloride
EC Number:
225-661-4
EC Name:
Cyclohexylammonium chloride
Cas Number:
4998-76-9
IUPAC Name:
cyclohexanaminium chloride
Details on test material:
no further data

Test animals

Species:
other: rat, rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: saline
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
once
Frequency of treatment:
once
Doses / concentrations
Remarks:
Doses / Concentrations:
37-148 mg/kg bw (calculated as cyclohexylamine)
Basis:

No. of animals per sex per dose:
no data
Control animals:
yes

Results and discussion

Any other information on results incl. tables

Cyclohexylamine hydrochloride is a weak central nervous system stimulant as evidenced by its ability to increase levels of sponatneous motor activity in mice at high doses.

Cyclohexylamine hydrochlolride exhibits weak antidepressant activity at high doses in the DOPA antidepressant test in mice. it is not a monoamine oxidase inhibitor (as evaluated in the mouse DOPA potentiation test.

Cyclohexylamine hydrochloride in the rabbit exhibits mild central nervous system stimulant properties when evaluated by EEG techniques.

Applicant's summary and conclusion