Registration Dossier
Registration Dossier
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EC number: 203-629-0 | CAS number: 108-91-8
Neurotoxicity
Administrative data
- Endpoint:
- neurotoxicity: acute oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
Data source
Reference
- Reference Type:
- other: microfiche
- Title:
- Cyclohexylamine: CNS studies
- Author:
- Air Prods & Chem Inc
- Year:
- 1 987
- Bibliographic source:
- EPA/OTS0540890
- Report date:
- 1968
Materials and methods
- Principles of method if other than guideline:
- 1. mouse symptomatology-toxicity
2. antidepressant suties in mice
3. EEG studies in rabbits - GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- Cyclohexylammonium chloride
- EC Number:
- 225-661-4
- EC Name:
- Cyclohexylammonium chloride
- Cas Number:
- 4998-76-9
- IUPAC Name:
- cyclohexanaminium chloride
- Details on test material:
- no further data
Constituent 1
Test animals
- Species:
- other: rat, rabbit
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: saline
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- once
- Frequency of treatment:
- once
Doses / concentrations
- Remarks:
- Doses / Concentrations:
37-148 mg/kg bw (calculated as cyclohexylamine)
Basis:
- No. of animals per sex per dose:
- no data
- Control animals:
- yes
Results and discussion
Any other information on results incl. tables
Cyclohexylamine hydrochloride is a weak central nervous system stimulant as evidenced by its ability to increase levels of sponatneous motor activity in mice at high doses.
Cyclohexylamine hydrochlolride exhibits weak antidepressant activity at high doses in the DOPA antidepressant test in mice. it is not a monoamine oxidase inhibitor (as evaluated in the mouse DOPA potentiation test.
Cyclohexylamine hydrochloride in the rabbit exhibits mild central nervous system stimulant properties when evaluated by EEG techniques.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
