Registration Dossier

Toxicological information

Exposure related observations in humans: other data

Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
other information

Data source

Reference
Reference Type:
publication
Title:
Studies on toxicity and skin effects of compounds used in the rubber and plastics industries
Author:
Mallette FS, Von Haam E.,
Year:
1952
Bibliographic source:
Arch. Ind. Hyg. Occup. Med.|5, 311-317

Materials and methods

Type of study / information:
in vivo skin irritation experiment with volunteers
Principles of method if other than guideline:
patch-testing method. Not less than 15 individuals were tested. The material was placed by patch on the skin of the back and remained for 48 hours.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Cyclohexylamine
EC Number:
203-629-0
EC Name:
Cyclohexylamine
Cas Number:
108-91-8
Molecular formula:
C6H13N
IUPAC Name:
cyclohexanamine
Details on test material:
no further data

Method

Ethical approval:
not specified
Details on study design:
patch-testing method. Not less than 15 individuals were tested. The material was placed by patch on the skin of the back and remained for 48 hours.
Exposure assessment:
measured
Details on exposure:
patch-testing method. Not less than 15 individuals were tested. The material was placed by patch on the skin of the back and remained for 48 hours.
25 % solution

Results and discussion

Results:
the voluteers showed severe irritational effects (no further details given)

Applicant's summary and conclusion